The hypocretins (H crts), also known as orexins, are two peptides derived from a single
precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin …

AgRP and POMC neurons are two key cell types that regulate feeding in response to
hormones and nutrients. Recently, it was discovered that these neurons are also rapidly …

DNA methylation is a regulatory mechanism in epigenetics that is frequently altered during
human carcinogenesis. To detect critical methylation events associated with gastric cancer …

BACKGROUND MUC16, encoding cancer antigen 125, is a frequently mutated gene in
gastric cancer. In addition, MUC16 mutations seem to result in a better prognosis in gastric …

The paraventricular nucleus (PVN) of the hypothalamus is an important center in regulating
the functions of internal organs, and it is the key nucleus for coordinating endocrine …

It has been well‐known that hypothalamic orexigenic neuropeptides, orexin‐A, and melanin‐
concentrating hormone (MCH), play important roles in regulation of gastric function …

Dopaminergic neurons play an important role on central regulatory mechanisms of feeding
behavior. Dopamine receptors are distributed within the hypothalamus and densely …

Orexin-A is mainly produced in the lateral hypothalamus (LHA) and the perifornical area
(PeF). Here, we aim to elucidate the effects of orexin-A in the hippocampus (Hi) on gastric …

Objective Abnormal gastric acid secretion and gastric dyskinesia are common
gastroenterological ailments. Our study aims to investigate the effect of orexin-A in the …

Methods: A guide cannula was stereotaxically implanted in PVN (coordinates: L:+ 0.4; DV: 7
AP:-1.8 mm) of male Wistar rats weighing 220-250 g. Sulpiride (0.1, 0.3, 0.75, 1.5, and 3μg) …