Pyroptosis is a form of cell death triggered by the innate immune system that has been
implicated in the pathogenesis of sepsis and acute lung injury. At the cellular level …

Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin
is reported to possess substantial anti‐inflammatory properties, which has proven to be …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and it is
characterised by progressive deterioration in cognitive and memory abilities, which can …

Inflammation is triggered by a repertoire of receptors detecting infections and damages.
Some of these receptors directly bind microbial ligands, while others recognize endogenous …

Scientists and health professionals are exhaustively trying to contain the coronavirus
disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible …

Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

The NLRP3 inflammasome can sense different pathogens or danger signals, and has been
reported to be involved in the development of many human diseases. Potassium efflux and …

The endoplasmic reticulum (ER) and mitochondria are tightly associated with very dynamic
platforms termed mitochondria-associated membranes (MAMs). MAMs provide an excellent …

Innate immunity is a rapidly evolving field with novel cell types and molecular pathways
being discovered and paradigms changing continuously. Innate and adaptive immune …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …