Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

Although the rates of many cancers are controlled in Western countries, those of some
cancers, such as lung, breast, and colorectal cancer are currently increasing in many low …

Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

Inflammation is a defense process triggered when the body faces assaults from pathogens,
toxic substances, microbial infections, or when tissue is damaged. Immune and inflammatory …

Hepatocellular death is a sensitive parameter for detecting acute liver injury (ALI) of toxic,
viral, metabolic, and autoimmune origin. Ferroptosis has recently been implicated in carbon …

The benevolent and detrimental effects of antioxidants are much debated in clinical trials
and cancer research. Several antioxidant enzymes and molecules are overexpressed in …

Abstract The Keap1‐Nrf2/ARE signaling pathway is an important defense system against
exogenous and endogenous oxidative stress injury. The dysregulation of the signaling …

Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism.
The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative …

Ischemic stroke, characterized by the sudden loss of blood flow in specific area (s) of the
brain, is the leading cause of permanent disability and is among the leading causes of death …

Ischemia/reperfusion (I/R) injury is associated with substantial clinical implications, including
a wide range of organs such as the brain, kidneys, lungs, heart, and many others. I/R injury …