Abstract PI3K-AKT/mTOR signaling pathway represents an essential signaling mechanism
for mammalian enzyme-related receptors in transducing signals or biological processes …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Biased agonism (or “functional selectivity”) at G-protein-coupled receptors has attracted
rapidly increasing interest as a means to improve discovery of more efficacious and safer …

Humans are inherently social beings. Being suggestible to each other's expectations
enables pro‐social skills that are crucial for social learning and adaptation. Despite their …

Depression is a psychosomatic disorder. The pharmacological treatment of depression has
been based on the pathophysiology of deficiency in monoamines, mainly serotonin and …

Chronic treatment with fluoxetine (FLX) is required for its antidepressant effects, but the role
of serotonin (5-HT) axonal plasticity in FLX action is unknown. To address this, we examined …

Major depressive disorder is a frequent and debilitating psychiatric disease. We have shown
in some of the acute animal models of major depressive disorder (tail suspension test and …

Introduction Pharmacotherapy of depression is characterized by the delayed onset of action,
chronic treatment requirements, and insufficient effectiveness. Ketamine, with its rapid action …

Neuropathic pain is a debilitating condition characterized by abnormal signaling within the
nervous system, resulting in persistent and often intense sensations of pain. It can arise from …

The retinoid family members, including vitamin A and derivatives like 13-cis-retinoic acid
(ITT) and all-trans retinoic acid (ATRA), are essential for normal functioning of the …