Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases
YV Sun, YJ Hu - Advances in genetics, 2016 - Elsevier
Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …
throughput technologies enable omics studies interrogating thousands to millions of makers …
DNA methylation markers in obesity, metabolic syndrome, and weight loss
M Samblas, FI Milagro, A Martínez - Epigenetics, 2019 - Taylor & Francis
The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …
Using recursive feature elimination in random forest to account for correlated variables in high dimensional data
Background Random forest (RF) is a machine-learning method that generally works well
with high-dimensional problems and allows for nonlinear relationships between predictors; …
with high-dimensional problems and allows for nonlinear relationships between predictors; …
DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …
(DNAm), underlie the relationship between adverse intrauterine conditions and adult …
Mitochondria and epigenetics–crosstalk in homeostasis and stress
Through epigenetic mechanisms cells integrate environmental stimuli to fine-tune gene
expression levels. Mitochondrial function is essential to provide the intermediate metabolites …
expression levels. Mitochondrial function is essential to provide the intermediate metabolites …
Association of body mass index with DNA methylation and gene expression in blood cells and relations to cardiometabolic disease: a Mendelian randomization …
Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …
the general population remains uncertain. Methods and Findings We conducted an …
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
EW Demerath, W Guan, ML Grove… - Human molecular …, 2015 - academic.oup.com
Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …
epigenetic modifications associated with elevated adiposity, including DNA methylation …
Blood leukocyte DNA methylation predicts risk of future myocardial infarction and coronary heart disease: a longitudinal study of 11 461 participants from population …
Background: DNA methylation is implicated in coronary heart disease (CHD), but current
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …
[HTML][HTML] Triglycerides and triglyceride-rich lipoproteins in the causal pathway of cardiovascular disease
M Budoff - The American journal of cardiology, 2016 - Elsevier
Epidemiologic and clinical studies suggest that elevated triglyceride levels are a biomarker
of cardiovascular (CV) risk. Consistent with these findings, recent genetic evidence from …
of cardiovascular (CV) risk. Consistent with these findings, recent genetic evidence from …