Theranostic signature of tumor-derived exosomes in cancer

S Kumar, R Dhar, LBSS Kumar, GG Shivji, R Jayaraj… - Medical Oncology, 2023 - Springer
Cancer is the most challenging global health crisis. In the recent times, studies on
extracellular vesicles (EVs) are adding a new chapter to cancer research and reports on EVs …

Immunotherapy with immune checkpoint inhibitors and predictive biomarkers in malignant mesothelioma: work still in progress

M Perrino, F De Vincenzo, N Cordua, F Borea… - Frontiers in …, 2023 - frontiersin.org
Malignant mesothelioma (MM) is a rare and aggressive neoplasm, usually associated with a
poor prognosis (5 years survival rate< 10%). For unresectable disease, platinum and …

Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma

I Fiorilla, S Martinotti, AM Todesco, G Bonsignore… - Cells, 2023 - mdpi.com
Malignant pleural mesothelioma (MPM) is a lethal and rare cancer, even if its incidence has
continuously increased all over the world. Asbestos exposure leads to the development of …

Inflammation of the pleural cavity: a review on pathogenesis, diagnosis and implications in tumor pathophysiology

G Karpathiou, M Péoc'h, A Sundaralingam, N Rahman… - Cancers, 2022 - mdpi.com
Simple Summary The pleura is a cavity whose pathology ranges from simple fluid
accumulation to tumor development, all inducing important consequences in patents health …

[HTML][HTML] ONCOS-102 plus pemetrexed and platinum chemotherapy in malignant pleural mesothelioma: a randomized phase 2 study investigating clinical outcomes …

S Ponce, S Cedrés, C Ricordel, N Isambert… - … for immunotherapy of …, 2023 - ncbi.nlm.nih.gov
Background ONCOS-102, an oncolytic adenovirus expressing granulocyte-macrophage
colony-stimulating factor, can alter the tumor microenvironment to an immunostimulatory …

Success of checkpoint blockade paves the way for novel immune therapy in malignant pleural mesothelioma

L Rondon, R Fu, MR Patel - Cancers, 2023 - mdpi.com
Simple Summary This review article will focus on the landmark studies that came to define
current treatment paradigms for malignant pleural mesothelioma (MPM), all the way from …

Exercise to transform tumours from cold to hot and improve immunotherapy responsiveness

B Hapuarachi, S Danson, J Wadsley… - Frontiers in …, 2023 - frontiersin.org
Exercise provides significant health benefits to patients diagnosed with cancer including
improved survival outcomes, quality of life and reduced cancer recurrence. Across multiple …

Mesothelioma malignancy and the microenvironment: molecular mechanisms

F Cersosimo, M Barbarino, S Lonardi, W Vermi… - Cancers, 2021 - mdpi.com
Simple Summary In the tumor microenvironment, interaction among tumor cells, immune
cells, stromal cells, and the extracellular matrix is vital to support pro-tumor mechanisms …

Activation of adaptive and innate immune cells via localized IL2 cytokine factories eradicates mesothelioma tumors

AM Nash, S Aghlara-Fotovat, B Castillio… - Clinical Cancer …, 2022 - AACR
Purpose: IL2 immunotherapy has the potential to elicit immune-mediated tumor lysis via
activation of effector immune cells, but clinical utility is limited due to pharmacokinetic …

Clinical, laboratory, histological, radiological, and metabolic features and prognosis of malignant pleural mesothelioma

Y Zhang, R Li, Y Gu, Y LiZhu, X Liu, S Zhang - Medicina, 2022 - mdpi.com
Background: Malignant pleural mesothelioma (MPM) is an aggressive and rare malignant
pleural tumor. Methods: MPM patients diagnosed in Beijing Chaoyang Hospital and Beijing …