Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells characterized by
their immunosuppressive functions. MDSCs expand during chronic and acute inflammatory …

Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a
major obstacle to curing HIV infection. Pharmacological activation of HIV expression in …

Pathogens have developed sophisticated strategies to evade the immune response, among
which manipulation of host cellular epigenetic mechanisms plays a prominent role. In the …

Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, have emerged as
critical mediators in the communication between the human microbiota and its host. As the …

Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory
effects, but whether they impact on antimicrobial host defenses remains largely unknown …

Macrophages have central roles in danger detection, inflammation and host defense, and
consequently, these cells are intimately linked to most disease processes. Major advances …

Macrophages function as sentinel cells, which constantly monitor the host environment for
infection or injury. Macrophages have been shown to exhibit a spectrum of activated …

Sepsis affects millions of people worldwide and is associated with acute kidney injury (AKI).
Innate and adaptive immune cells have been shown to play an important role in AKI through …

Histone modifications control numerous processes in eukaryotes, including inflammation.
Some bacterial pathogens alter the activity or expression of host-derived factors, including …