Pathogenesis of asthma

ST Holgate - Clinical & Experimental Allergy, 2008 - Wiley Online Library
While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

The mechanisms, diagnosis, and management of severe asthma in adults

ST Holgate, R Polosa - The Lancet, 2006 - thelancet.com
There has been a recent increase in the prevalence of asthma worldwide; however, the 5–
10% of patients with severe disease account for a substantial proportion of the health costs …

Hematopoietic cell transplantation cures adenosine deaminase 2 deficiency: report on 30 patients

H Hashem, G Bucciol, S Ozen, S Unal… - Journal of clinical …, 2021 - Springer
Purpose Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of
immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo …

Clinical significance of hyperattenuating mucoid impaction in allergic bronchopulmonary aspergillosis: an analysis of 155 patients

R Agarwal, D Gupta, AN Aggarwal, AK Saxena… - Chest, 2007 - Elsevier
Background Allergic bronchopulmonary aspergillosis (ABPA) is a disease that presents with
diverse clinicoradiologic manifestations. High-attenuation mucus (HAM) is a characteristic …

Fungi in the cystic fibrosis lung: bystanders or pathogens?

SH Chotirmall, NG McElvaney - The international journal of biochemistry & …, 2014 - Elsevier
Improvement to the life expectancy of people with cystic fibrosis (PWCF) brings about novel
challenges including the need for evaluation of the role of fungi in the cystic fibrosis (CF) …

The Effect of Aspergillus fumigatus Infection on Vitamin D Receptor Expression in Cystic Fibrosis

CA Coughlan, SH Chotirmall, J Renwick… - American journal of …, 2012 - atsjournals.org
Rationale: Aspergillus fumigatus (A. fumigatus) in cystic fibrosis (CF) is increasingly
recognized. Although allergic bronchopulmonary aspergillosis (ABPA) leads to deterioration …

Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype

S Bhatia, M Fei, M Yarlagadda, Z Qi, S Akira, S Saijo… - PloS one, 2011 - journals.plos.org
The ubiquitous fungus Aspergillus fumigatus is associated with chronic diseases such as
invasive pulmonary aspergillosis in immunosuppressed patients and allergic …

Electronic nose technology for detection of invasive pulmonary aspergillosis in prolonged chemotherapy-induced neutropenia: a proof-of-principle study

K de Heer, MP van der Schee… - Journal of clinical …, 2013 - Am Soc Microbiol
Although the high mortality rate of pulmonary invasive aspergillosis (IA) in patients with
prolonged chemotherapy-induced neutropenia (PCIN) can be reduced by timely diagnosis …

Aspergillus hypersensitivity in patients with chronic obstructive pulmonary disease: COPD as a risk factor for ABPA?

R Agarwal, B Hazarika, D Gupta, AN Aggarwal… - Medical …, 2010 - academic.oup.com
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder caused by
hypersensitivity to Aspergillus fumigatus which primarily complicates the course of asthma …

Treatment of allergic bronchopulmonary aspergillosis (ABPA) in CF with anti‐IgE antibody (omalizumab)

A Kanu, K Patel - Pediatric pulmonology, 2008 - Wiley Online Library
Allergic bronchopulmonary aspergillosis (ABPA) results from IgE induced pulmonary
response to aspergillus species. Recognition and management of ABPA is challenging in …