When in a patient more than one tumour in the same or a different organ is diagnosed,
multiple primary tumours may be present. For epidemiological studies, different definitions of …

Over 1.66 million humans (approx. 500/100 000 population rate) and over 4.2 million dogs
(approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The …

Background The purpose of this consensus guideline is to outline recommendations for
genetic testing that medical professionals can use to assess hereditary risk for breast …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Human cancers arise from environmental, heritable and somatic factors, but how these
mechanisms interact in tumorigenesis is poorly understood. Studying 17,152 prospectively …

How can we treat cancer more effectively? Traditionally, tumours from the same anatomical
site are treated as one tumour entity. This concept has been challenged by recent …

Background Genetic testing for risk of hereditary cancer can help patients to make important
decisions about prevention or early detection. US and UK studies show that people from …

All malignant cancers, whether inherited or sporadic, are fundamentally governed by
Darwinian dynamics. The process of carcinogenesis requires genetic instability and highly …

Breast cancer is the most common malignancy among females. 5%–10% of breast cancer
cases are hereditary and are caused by pathogenic mutations in the considered reference …

Background Cancer has long inspired fear, but the effect of fear is not well understood; it
seems both to facilitate and to deter early diagnosis behaviours. To elucidate fear's …