A series of cascade reactions that produce a range of functionalized aromatic heterocyclic
compounds with pyrazole/pyrazoline cores have been developed. The method relies on a …

Malignant neoplasms are one of the leading causes of death worldwide and hematologic
malignancies, including acute leukemia (AL) is one of the most relevant cancer types …

Chalcones and their derivatives have been described as promising compounds with
antiproliferative activity against leukemic cells. This study aimed to investigate the cytotoxic …

A novel ionic liquid-coated nanomaterials (CaO@ SiO2@ BAIL) was successfully
synthesized by anchoring the 1-(3-(trimethoxysilyl) propyl)-1, 3, 5, 7-tetraazaadamantan-1 …

Abstract Scientific evidences have highlighted 5-(1-(3-fluorophenyl)-1H-pyrazol-4-yl)-2H-
tetrazole (LQFM021) as a promising anti-inflammatory, analgesic and antinociceptive agent …

Background: Current therapies for acute leukemias (ALs) are associated with severe
adverse reactions and high relapse rates, which makes the search for new antileukemic …

Acute leukemias are a heterogeneous group of aggressive malignant neoplasms associated
with severe morbidities due to the nonselectivity of current chemotherapeutic drugs to …

The 2-pyrazoline derivatives have a wide range of biological effects, such as anti-viral, anti-
bacterial, anti-fungal, anti-depressant and anti-cancer effects. Studies have shown that …

Inflammatory diseases are characterized by inflammation that can affect any system and can
have multiple etiologies. Among inflammation sources, some bacterial infections can …

O câncer é responsável por mais de 8, 2 milhões de mortes em todo mundo, tornando-se
um grave problema de saúde pública mundial. Embora seja vasta a lista de fármacos …