NK cells in HIV disease

E Scully, G Alter - Current HIV/AIDS Reports, 2016 - Springer
Natural killer (NK) cells play a critical role in viral immunity. In the setting of HIV infection,
epidemiologic and functional evidence support a role for NK cells in both protection from …

The B-cell follicle in HIV infection: barrier to a cure

MP Bronnimann, PJ Skinner, E Connick - Frontiers in immunology, 2018 - frontiersin.org
The majority of HIV replication occurs in secondary lymphoid organs (SLOs) such as the
spleen, lymph nodes, and gut-associated lymphoid tissue. Within SLOs, HIV RNA+ cells are …

Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys

N Huot, B Jacquelin, T Garcia-Tellez, P Rascle… - Nature medicine, 2017 - nature.com
Natural killer (NK) cells play an essential role in antiviral immunity, but knowledge of their
function in secondary lymphoid organs is incomplete. Lymph node follicles constitute a …

CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells

A Kurioka, C Cosgrove, Y Simoni… - Frontiers in …, 2018 - frontiersin.org
CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells;
however, the significance of CD161 expression on NK cells has not been comprehensively …

Impact of the timing of initiation of antiretroviral therapy during primary HIV-1 infection on the decay of cell-associated HIV-DNA

M Laanani, J Ghosn, A Essat, A Melard… - Clinical Infectious …, 2015 - academic.oup.com
Background. Combined antiretroviral therapy (cART) initiation during primary human
immunodeficiency virus (HIV) infection (PHI) yields a larger decrease in cell-associated HIV …

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

N Huot, P Rascle, C Petitdemange, V Contreras… - Nature …, 2021 - nature.com
Natural killer (NK) cells play a critical understudied role during HIV infection in tissues. In a
natural host of SIV, the African green monkey (AGM), NK cells mediate a strong control of …

A novel acute HIV infection staging system based on 4thgeneration immunoassay

J Ananworanich, JLK Fletcher, S Pinyakorn… - Retrovirology, 2013 - Springer
Background Fourth generation (4thG) immunoassay (IA) is becoming the standard HIV
screening method but was not available when the Fiebig acute HIV infection (AHI) staging …

Small CD4 mimetics prevent HIV-1 uninfected bystander CD4+ T cell killing mediated by antibody-dependent cell-mediated cytotoxicity

J Richard, M Veillette, S Ding, D Zoubchenok… - …, 2016 - thelancet.com
Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of
CD4+ T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms …

Remodeling of the host cell plasma membrane by HIV-1 Nef and Vpu: a strategy to ensure viral fitness and persistence

SM Sugden, MG Bego, TNQ Pham, ÉA Cohen - Viruses, 2016 - mdpi.com
The plasma membrane protects the cell from its surroundings and regulates cellular
communication, homing, and metabolism. Not surprisingly, the composition of this …

Transcriptome-based analysis of human peripheral blood reveals regulators of immune response in different viral infections

SM Ivanov, OA Tarasova, VV Poroikov - Frontiers in Immunology, 2023 - frontiersin.org
Introduction There are difficulties in creating direct antiviral drugs for all viruses, including
new, suddenly arising infections, such as COVID-19. Therefore, pathogenesis-directed …