[HTML][HTML] Current strategies of antiviral drug discovery for COVID-19

M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …

The JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms

C Baldini, FR Moriconi, S Galimberti… - European Heart …, 2021 - academic.oup.com
Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …

A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice

T Mao, B Israelow, C Lucas, CBF Vogels… - Journal of Experimental …, 2021 - rupress.org
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an
urgent need for the development of effective medical countermeasures. Here, we assessed …

[HTML][HTML] Diverse immunological factors influencing pathogenesis in patients with COVID-19: a review on viral dissemination, immunotherapeutic options to counter …

AA Rabaan, SH Al-Ahmed, MA Garout, AM Al-Qaaneh… - Pathogens, 2021 - mdpi.com
The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though …

Tocilizumab administration for the treatment of hospitalized patients with COVID‐19: a systematic review and meta‐analysis

C Kyriakopoulos, G Ntritsos, A Gogali, H Milionis… - …, 2021 - Wiley Online Library
Tocilizumab has been repurposed against the 'cytokine storm'in the setting of coronavirus
disease 2019 (COVID‐19). Our aim was to evaluate the efficacy of tocilizumab in the …

[HTML][HTML] Baricitinib combination therapy: a narrative review of repurposed Janus kinase inhibitor against severe SARS-CoV-2 infection

M Akbarzadeh-Khiavi, M Torabi, L Rahbarnia, A Safary - Infection, 2022 - Springer
Abstract Purpose The Coronavirus disease 2019 (COVID-19) pandemic is one of the most
devastating global problems. Regarding the lack of disease-specific treatments, repurposing …

Treatment and prevention strategies for the COVID 19 pandemic: a review of immunotherapeutic approaches for neutralizing SARS-CoV-2

PK Baral, J Yin, MNG James - International journal of biological …, 2021 - Elsevier
Researchers from the world over are working to create prophylactic and therapeutic
interventions to combat the COVID-19 global healthcare crisis. The current therapeutic …

[HTML][HTML] Recent advances in JAK inhibitors for the treatment of metabolic syndrome

D Collotta, MP Franchina, V Carlucci… - Frontiers in …, 2023 - frontiersin.org
With an epidemic spread, metabolic syndrome represents an increasingly emerging risk for
the population globally, and is currently recognized as a pathological entity. It is represented …

Therapeutic and anti-inflammatory effects of baricitinib on mortality, ICU transfer, clinical improvement, and CRS-related laboratory parameters of hospitalized patients …

S Tahsini Tekantapeh, M Ghojazadeh… - Expert Review of …, 2022 - Taylor & Francis
Background Due to the high incidence and mortality of the worldwide COVID-19 pandemic,
beneficial effects of effective antiviral and anti-inflammatory drugs used in other diseases …

[HTML][HTML] I've looked at gut from both sides now: Gastrointestinal tract involvement in the pathogenesis of SARS-CoV-2 and HIV/SIV infections

I Pandrea, K Brooks, RP Desai, M Tare… - Frontiers in …, 2022 - frontiersin.org
The lumen of the gastrointestinal (GI) tract contains an incredibly diverse and extensive
collection of microorganisms that can directly stimulate the immune system. There are …