Silver-Russell syndrome (SRS) and Beckwith-Wiedemann syndrome (BWS) are 2 clinically
opposite growth-affecting disorders belonging to the group of congenital imprinting …

Improvements in our understanding of the genetic basis of human disease and increased
utilization of genetic testing have identified a variety of heritable disorders associated with …

Abstract Beckwith–Wiedemann Syndrome (BWS) is an overgrowth syndrome caused by a
variety of molecular changes on chromosome 11p15. 5. Children with BWS have a …

Routine use of ultrasonography in general pediatric practice, even following very mild and
nonspecific abdominal symptoms, has dramatically increased the detection of focal hepatic …

The increased application of germline genetic testing is expanding our understanding of the
risk factors associated with childhood cancer development, and, in some cases, such testing …

Beckwith–Wiedemann syndrome (BWS) and isolated hemihyperplasia (IHH) are two well
known overgrowth conditions that are associated with cancer predisposition. Multiple …

Beckwith–Wiedemann syndrome (BWS) is an overgrowth disorder with variability in clinical
manifestations and molecular causes. In most cases, patients with BWS have normal …

Purpose Individuals with cancer predisposition syndromes (CPS) are often followed in
cancer screening programs, which aim to detect early stage tumors. While cancer …

The PIK3CA‐related overgrowth spectrum (PROS) encompasses various conditions caused
by mosaic activating PIK3CA variants. PIK3CA somatic variants are also involved in various …

Beckwith–Wiedemann syndrome (BWS) is the most common imprinting disorder and
consequently, one of the most common cancer predisposition disorders. Over the past 20 …