Purpose Individuals with cancer predisposition syndromes (CPS) are often followed in
cancer screening programs, which aim to detect early stage tumors. While cancer …

Purpose: Unilateral Wilms tumors associated with predisposing syndromes are treated with
preoperative chemotherapy followed by surgical resection. We describe our experience with …

The clinical management of familial cancer begins with recognition of patterns of cancer
occurrence suggestive of genetic susceptibility in a proband or pedigree, to enable …

Background Clinical experience shows that the primary diagnosis of mesenchymal
hamartoma (MHL) and embryonal sarcoma of the liver (ESL) recurrently is mistaken, leading …

Overgrowth syndromes comprise a diverse group of conditions with unique clinical,
behavioral and molecular genetic features. While considerable overlap in presentation …

This paper outlines the major components and function of the technologically integrated
oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer …

Beckwith–Wiedemann syndrome is an overgrowth disorder characterized by neonatal
macrosomia, abdominal wall defects, macroglossia, renal anomalies, organomegaly …

The three most common pediatric solid tumors of the abdomen are neuroblastoma, Wilms
tumor, and hepatoblastoma. These embryonal tumors most commonly present in the first …

Advances in the understanding of cancer predisposition and implementation of standardized
cancer surveillance protocols have improved the outcome for certain patients. Future …

Background: There is a reported increased risk of intra-abdominal tumors in children with
both syndromic (SH) and isolated idiopathic hemihyperplasia (IH). Recommendations for …