Understanding Pseudomonas aeruginosa–Host Interactions: The Ongoing Quest for an Efficacious Vaccine

M Sainz-Mejías, I Jurado-Martín, S McClean - Cells, 2020 - mdpi.com
Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with
cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and …

Antibiotic-resistant ESKAPE pathogens and COVID-19: the pandemic beyond the pandemic

A Catalano, D Iacopetta, J Ceramella, M Pellegrino… - Viruses, 2023 - mdpi.com
Antibacterial resistance is a renewed public health plague in modern times, and the COVID-
19 pandemic has rekindled this problem. Changes in antibiotic prescribing behavior …

Adding insult to injury: mechanistic basis for how AmpC mutations allow Pseudomonas aeruginosa to accelerate cephalosporin hydrolysis and evade avibactam

CL Slater, J Winogrodzki, PA Fraile-Ribot… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Pseudomonas aeruginosa is a leading cause of nosocomial infections worldwide and
notorious for its broad-spectrum resistance to antibiotics. A key mechanism that provides …

Accelerated antibiotic susceptibility testing of Pseudomonas aeruginosa by monitoring extracellular electron transfer on a 3-D paper-based cell culture platform

Z Rafiee, M Rezaie, S Choi - Biosensors and Bioelectronics, 2022 - Elsevier
Pseudomonas aeruginosa is the most important opportunistic pathogen leading to serious
and life-threatening infections, especially in immunocompromised patients. Because of its …

DNA Methyltransferase regulates nitric oxide homeostasis and virulence in a chronically adapted Pseudomonas aeruginosa strain

S Han, J Liu, M Li, Y Zhang, X Duan, Y Zhang… - …, 2022 - Am Soc Microbiol
Opportunistic pathogens such as Pseudomonas aeruginosa adapt their genomes rapidly
during chronic infections. Understanding their epigenetic regulation may provide biomarkers …

The primary pharmacology of ceftazidime/avibactam: microbiology from clinical studies, and development of resistance during treatment

WW Nichols, PA Bradford… - Journal of Antimicrobial …, 2023 - academic.oup.com
As one of a series of thematically linked reviews of the primary pharmacology of the β-
lactam/β-lactamase inhibitor combination, ceftazidime/avibactam, this article reviews the …

Development of innovative multi-epitope mRNA vaccine against Pseudomonas aeruginosa using in silico approaches

M Asadinezhad, S Khoshnood… - Briefings in …, 2024 - academic.oup.com
The rising issue of antibiotic resistance has made treating Pseudomonas aeruginosa
infections increasingly challenging. Therefore, vaccines have emerged as a viable …

[HTML][HTML] Comparative genomics and DNA methylation analysis of Pseudomonas aeruginosa clinical isolate PA3 by single-molecule real-time sequencing reveals new …

Z Li, X Zhou, D Liao, R Liu, X Zhao, J Wang… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Methods This study applied SMRT technology to sequence a clinical strain P. aeruginosa
PA3 to obtain its genome sequence and methylation modification information. Genomic …

Prediction of Potential Drug Targets and Vaccine Candidates Against Antibiotic-Resistant Pseudomonas aeruginosa

FS Shamsinejad, Z Zafari - International Journal of Peptide Research and …, 2022 - Springer
Pseudomonas aeruginosa is one of the leading causes of nosocomial infections,
characterized by increasing antibiotic resistance, severity and mortality. Therefore …

Advances in Development of Novel Therapeutic Strategies against Multi-Drug Resistant Pseudomonas aeruginosa

C Yin, MZ Alam, JT Fallon, W Huang - Antibiotics, 2024 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) with multi-drug resistance (MDR) is a major
cause of serious healthcare-associated infections, leading to high morbidity and mortality …