Recent updates of carbapenem antibiotics
MI El-Gamal, I Brahim, N Hisham, R Aladdin… - European journal of …, 2017 - Elsevier
Carbapenems are among the most commonly used and the most efficient antibiotics since
they are relatively resistant to hydrolysis by most β-lactamases, they target penicillin-binding …
they are relatively resistant to hydrolysis by most β-lactamases, they target penicillin-binding …
Applications of the pharmacokinetic/pharmacodynamic (PK/PD) analysis of antimicrobial agents
E Asín-Prieto, A Rodríguez-Gascón, A Isla - Journal of Infection and …, 2015 - Elsevier
The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …
Comparative review of imipenem/cilastatin versus meropenem
A Salmon-Rousseau, C Martins, M Blot… - Médecine et Maladies …, 2020 - Elsevier
Introduction Carbapenems are broad-spectrum antibacterial molecules. Imipenem-cilastatin
and meropenem are the two main molecules used in French healthcare services. Objective …
and meropenem are the two main molecules used in French healthcare services. Objective …
Antibiotics in the biliary tract: a review of the pharmacokinetics and clinical outcomes of antibiotics penetrating the bile and gallbladder wall
AK Thabit - … : The Journal of Human Pharmacology and Drug …, 2020 - Wiley Online Library
Biliary tract infections (BTIs), including cholangitis and cholecystitis, are common causes of
bacteremia. Bacteremic BTIs are associated with a mortality rate of 9–12%. The extent to …
bacteremia. Bacteremic BTIs are associated with a mortality rate of 9–12%. The extent to …
Prediction of tissue exposures of Meropenem, Colistin, and Sulbactam in pediatrics using physiologically based pharmacokinetic modeling
Background The combination of polymyxins, meropenem, and sulbactam demonstrated
efficacy against multi-drug-resistant bacillus Acinetobacter baumannii. These three …
efficacy against multi-drug-resistant bacillus Acinetobacter baumannii. These three …
Physiologically based pharmacokinetic modeling of meropenem in preterm and term infants
S Ganguly, AN Edginton, JG Gerhart… - Clinical …, 2021 - Springer
Background Meropenem is a broad-spectrum carbapenem antibiotic approved by the US
Food and Drug Administration for use in pediatric patients, including treating complicated …
Food and Drug Administration for use in pediatric patients, including treating complicated …
Pharmacokinetics and target attainment of ß-lactam antibiotics in older people: a systematic review of current literature
J Vervalcke, A De Clercq, P De Paepe… - Clinical …, 2023 - Springer
Background and objective (Patho) physiological changes in older people may influence the
pharmacokinetics (PK), and consequently the target attainment, of ß-lactam antibiotics using …
pharmacokinetics (PK), and consequently the target attainment, of ß-lactam antibiotics using …
Is meropenem as a monotherapy truly incompetent for meropenem-nonsusceptible bacterial strains? A pharmacokinetic/pharmacodynamic modeling with Monte …
X Song, Y Wu, L Cao, D Yao, M Long - Frontiers in Microbiology, 2019 - frontiersin.org
Infections due to meropenem-nonsusceptible bacterial strains (MNBSs) with meropenem
minimum inhibitory concentrations (MICs)≥ 16 mg/L have become an urgent problem …
minimum inhibitory concentrations (MICs)≥ 16 mg/L have become an urgent problem …
Biofilm infections between Scylla and Charybdis: interplay of host antimicrobial peptides and antibiotics
S Chernysh, N Gordya, D Tulin… - Infection and drug …, 2018 - Taylor & Francis
Purpose: The aim of this study is to improve the anti-biofilm activity of antibiotics. We
hypothesized that the antimicrobial peptide (AMP) complex of the host's immune system can …
hypothesized that the antimicrobial peptide (AMP) complex of the host's immune system can …