Extracellular vesicles (EVs) deliver genes and proteins to recipient cells, and mediate
paracrine actions of their parent cells. Intrarenal delivery of mesenchymal stem cell (MSC) …

Macrophages are heterogenous cells of the innate immune system that can fluidly modulate
their phenotype to respond to their local microenvironment. They are found throughout the …

Results of recent clinical trials and experimental studies indicate that whereas
atherosclerotic renovascular disease can accelerate both systemic hypertension and tissue …

Almost a hundred years have passed since obstruction of the renal artery has been
recognized to raise blood pressure. By now chronic renovascular disease (RVD) due to …

Aims Neuroinflammation is a common feature in renovascular, obesity-related, and
angiotensin II mediated hypertension. There is evidence that increased release of the pro …

Cell stress may give rise to insuperable growth arrest, which is defined as cellular
senescence. Stenotic kidney (STK) ischemia and injury induced by renal artery stenosis …

Tissue fibrosis is characterized by excessive deposition of extracellular matrix (ECM)
components that result from the disruption of regulatory processes responsible for ECM …

Aims Mesenchymal stromal/stem cell (MSC)-derived extracellular vesicles (EVs) shuttle
select MSC contents and are endowed with an ability to repair ischemic tissues. We …

Introduction Obesity is a health burden that impairs cellular processes. Mesenchymal
stem/stromal cells (MSCs) are endowed with reparative properties and can ameliorate renal …

Ischaemic renal disease as result of atherosclerotic renovascular disease activates a
complex biological response that ultimately leads to fibrosis and chronic kidney disease …