[HTML][HTML] Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2

B Bathish, H Robertson, JF Dillon… - Free Radical Biology …, 2022 - Elsevier
Non-alcoholic steatohepatitis (NASH) represents a global health concern. It is characterised
by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity …

Mechanisms of feedback regulation of vitamin A metabolism

C O'Connor, P Varshosaz, AR Moise - Nutrients, 2022 - mdpi.com
Vitamin A is an essential nutrient required throughout life. Through its various metabolites,
vitamin A sustains fetal development, immunity, vision, and the maintenance, regulation, and …

[HTML][HTML] Carotenoids in health as studied by omics-related endpoints

T Bohn, E Balbuena, H Ulus, M Iddir, G Wang… - Advances in …, 2023 - Elsevier
Carotenoids have been associated with risk reduction for several chronic diseases,
including the association of their dietary intake/circulating levels with reduced incidence of …

Gut microbiota-testis axis: FMT mitigates high-fat diet-diminished male fertility via improving systemic and testicular metabolome

Y Hao, Y Feng, X Yan, L Chen, X Ma, X Tang… - Microbiology …, 2022 - Am Soc Microbiol
ABSTRACT High-fat diet (HFD)-induced obesity is known to be associated with reduced
male fertility and decreased semen quality in humans. HFD-related male infertility is a …

The role of vitamin A in non-ruminant immunology

Y Shastak, W Pelletier - Frontiers in Animal Science, 2023 - frontiersin.org
Vitamin A (retinol) is an essential micronutrient with a crucial role in the immune system of
non-ruminant animals, such as swine and poultry. It includes three chemical compounds …

[HTML][HTML] Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1-and G6PC-mediated gluconeogenesis

H Yang, M Su, M Liu, Y Sheng, L Zhu, L Yang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Abstract Type 2 diabetes (T2D) is often accompanied with an induction of retinaldehyde
dehydrogenase 1 (RALDH1 or ALDH1A1) expression and a consequent decrease in …

Retinoids in the pathogenesis and treatment of liver diseases

M Melis, XH Tang, SE Trasino, LJ Gudas - Nutrients, 2022 - mdpi.com
Vitamin A (VA), all-trans-retinol (ROL), and its analogs are collectively called retinoids.
Acting through the retinoic acid receptors RARα, RARβ, and RARγ, all-trans-retinoic acid, an …

[HTML][HTML] Vitamin A reduces the mortality of animals with induced liver fibrosis by providing a multi-level body defense system

AI Bozhkov, AV Novikova, EM Klimova, IA Ionov… - Journal of Clinical and …, 2023 - Elsevier
Background Liver diseases remain the most important medical and biological problem.
Works devoted to the study of the vitamin A role have shown conflicting results of its effect on …

Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study

RS Ibrahim, NS El-Mezayen, AA El‐Banna - Scientific Reports, 2022 - nature.com
Liver cirrhosis is a late-stage liver disease characterized by excessive fibrous deposition
triggering portal-hypertension (PH); the prime restrainer for cirrhosis-related complications …

Dietary vitamin A affects growth performance, immunity, antioxidant capacity, and lipid metabolism of juvenile Chinese mitten crab Eriocheir sinensis

Q Huang, X Wang, X Bu, Y Song, J You, C Zhang… - Aquaculture, 2022 - Elsevier
The effects of dietary vitamin A level on the growth performance, immunity, oxidation
resistance and lipid metabolism of juvenile Chinese mitten crab Eriocheir sinensis …