The neuroimmune axis of Alzheimer's disease

M Jorfi, A Maaser-Hecker, RE Tanzi - Genome Medicine, 2023 - Springer
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

Microglial activation and tau propagate jointly across Braak stages

TA Pascoal, AL Benedet, NJ Ashton, MS Kang… - Nature medicine, 2021 - nature.com
Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …

The neuroimmunology of social-stress-induced sensitization

RG Biltz, CM Sawicki, JF Sheridan, JP Godbout - Nature immunology, 2022 - nature.com
Myriad clinical findings provide links between chronic stressors, inflammation, and mood
disorders. Furthermore, traumatic or chronic exposure to psychological stressors may …

The role of the immune system in posttraumatic stress disorder

S Katrinli, NCS Oliveira, JC Felger… - Translational …, 2022 - nature.com
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …

Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

R Rupprecht, CH Wetzel, M Dorostkar, J Herms… - Molecular …, 2022 - nature.com
Efficient treatment of stress-related disorders, such as depression, is still a major challenge.
The onset of antidepressant drug action is generally quite slow, while the anxiolytic action of …

Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic …

B Ben-Azu, OG Adebayo, EG Moke… - Journal of Psychiatric …, 2023 - Elsevier
Geraniol is an acyclic isoprenoid monoterpenoid analogue that has been shown to elicit
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …

Parasympathetic autonomic dysfunction is more often evidenced than sympathetic autonomic dysfunction in fluctuating and polymorphic symptoms of" long-COVID" …

A Zanin, G Amah, S Chakroun, P Testard, A Faucher… - Scientific Reports, 2023 - nature.com
Several disabling symptoms potentially related to dysautonomia have been reported in “long-
COVID” patients. Unfortunately, these symptoms are often nonspecific, and autonomic …

Stress-related dysfunction of adult hippocampal neurogenesis—an attempt for understanding resilience?

J Leschik, B Lutz, A Gentile - International Journal of Molecular Sciences, 2021 - mdpi.com
Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …

Decoding shared versus divergent transcriptomic signatures across cortico-amygdala circuitry in PTSD and depressive disorders

AE Jaffe, R Tao, SC Page, KR Maynard… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease
that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The …