The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
Dopamine, immunity, and disease
B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …
regulating many processes including reward, movement, and cognition. Dopamine also …
Microglial activation and tau propagate jointly across Braak stages
Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
The neuroimmunology of social-stress-induced sensitization
Myriad clinical findings provide links between chronic stressors, inflammation, and mood
disorders. Furthermore, traumatic or chronic exposure to psychological stressors may …
disorders. Furthermore, traumatic or chronic exposure to psychological stressors may …
The role of the immune system in posttraumatic stress disorder
S Katrinli, NCS Oliveira, JC Felger… - Translational …, 2022 - nature.com
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …
Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?
Efficient treatment of stress-related disorders, such as depression, is still a major challenge.
The onset of antidepressant drug action is generally quite slow, while the anxiolytic action of …
The onset of antidepressant drug action is generally quite slow, while the anxiolytic action of …
Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic …
Geraniol is an acyclic isoprenoid monoterpenoid analogue that has been shown to elicit
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …
neuroprotective functions, primarily through its ability to stimulate antioxidant and anti …
Parasympathetic autonomic dysfunction is more often evidenced than sympathetic autonomic dysfunction in fluctuating and polymorphic symptoms of" long-COVID" …
A Zanin, G Amah, S Chakroun, P Testard, A Faucher… - Scientific Reports, 2023 - nature.com
Several disabling symptoms potentially related to dysautonomia have been reported in “long-
COVID” patients. Unfortunately, these symptoms are often nonspecific, and autonomic …
COVID” patients. Unfortunately, these symptoms are often nonspecific, and autonomic …
Stress-related dysfunction of adult hippocampal neurogenesis—an attempt for understanding resilience?
Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …
Decoding shared versus divergent transcriptomic signatures across cortico-amygdala circuitry in PTSD and depressive disorders
Objective: Posttraumatic stress disorder (PTSD) is a debilitating neuropsychiatric disease
that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The …
that is highly comorbid with major depressive disorder (MDD) and bipolar disorder. The …