In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Ribosomal protein genes are among the most highly expressed genes in most cell types.
Their products are generally essential for ribosome synthesis, which is the cornerstone for …

Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …

Piwi-interacting RNAs (piRNAs) are RNA effectors with key roles in maintaining genome
integrity and promoting fertility in metazoans. In Caenorhabditis elegans loss of piRNAs …

Zinc is an essential cofactor for many proteins. A key mechanism of zinc homeostasis during
deficiency is “zinc sparing” in which specific zinc-binding proteins are repressed to reduce …

We discuss novel insight into the role and consequences of the phosphorylation of the
translation initiation factor eIF2α in the context of stress responses and cell-cycle regulation …

Transcription regulation underlies stem cell function and development. Here, we elucidate
an unexpected role of an essential ribogenesis factor, WDR43, as a chromatin-associated …

Eukaryotic ribosome biogenesis is facilitated and regulated by numerous ribosome
biogenesis factors (RBFs). High-resolution cryoelectron microscopy (cryo-EM) maps have …

Protein biosynthesis is a conserved process, essential for life. Ongoing research for four
decades has revealed the structural basis and mechanistic details of most protein …

Intron branchpoint (BP) recognition by the U2 snRNP is a critical step of splicing, vulnerable
to recurrent cancer mutations and bacterial natural product inhibitors. The BP binds a …