Shedding Valuable Tears: Tear Fluid as a Promising Source of Disease Biomarkers

IS Vavilina, AA Shpak, TA Druzhkova, AB Guekht… - Neurochemical …, 2023 - Springer
The simplicity of collecting and evaluating tear fluid (TF) can potentially provide a convenient
non-invasive diagnostic tool that easily fits into a personalized approach to medicine based …

Corneal epithelium models for safety assessment in drug development: Present and future directions

RK Abdalkader, T Fujita - Experimental Eye Research, 2023 - Elsevier
The human corneal epithelial barrier plays a crucial role in drug testing studies, including
drug absorption, distribution, metabolism, and excretion (ADME), as well as toxicity testing …

[HTML][HTML] Cyclosporine a decreases dryness-induced hyperexcitability of corneal cold-sensitive nerve terminals

A Gyenes, Z Tapasztó, S Quirce, C Luna… - International Journal of …, 2023 - mdpi.com
Cyclosporine A (CsA) is used for the treatment of dry eye (DE) with good clinical results,
improving tear secretion and decreasing subjective symptoms. These effects are attributed …