Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …

Schizophrenia is a devastating mental illness with a strong genetic component that is the
subject of extensive research. Despite the high heritability, it is well recognized that non …

Schizophrenia has been an evolutionary paradox: it has high heritability, but it is associated
with decreased reproductive success. The causal genetic variants underlying schizophrenia …

Schizophrenia is a severe neuropsychiatric disorder with persistence of symptoms
throughout adult life in most of the affected patients. This unfavorable course is associated …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

An interaction between external stressors and intrinsic vulnerability is one of the longest
standing pathoaetiological explanations for schizophrenia. However, novel lines of evidence …

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in
psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of …

The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …

During the last decades, schizophrenia has been regarded as a developmental disorder.
The neurodevelopmental hypothesis proposes schizophrenia to be related to genetic and …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …