Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

Recent understanding of how the systemic environment shapes the brain throughout life has
led to numerous intervention strategies to slow brain ageing,–. Cerebrospinal fluid (CSF) …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …

Astrocytes provide key neuronal support, and their phenotypic transformation is implicated in
neurodegenerative diseases. Metabolically, astrocytes possess low mitochondrial oxidative …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

All mammalian cell membranes contain cholesterol to maintain membrane integrity. The
transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially …

In Alzheimer's disease (AD), Aβ deposits form slowly, several decades before further
pathological events trigger neurodegeneration and dementia. However, a substantial …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …