Age-related myelin damage induces inflammatory responses, yet its involvement in
Alzheimer's disease remains uncertain, despite age being a major risk factor. Using a …

Background Substantial evidence suggests that immunoproteasome is implicated in the
various neurological diseases such as stroke, multiple sclerosis and neurodegenerative …

Alzheimer's disease is a neurodegenerative disease caused by excessive amyloid β protein-
induced neurotoxicity. However, drugs targeting amyloid β protein production face many …

The action potential conduction along the axon is highly dependent on the healthy
interactions between the axon and myelin-producing glial cells. Myelin, which facilitates …

Clinical and basic neuroscience research is greatly benefited from the identification and
characterization of lineage specific and developmental stage‐specific markers. In the glial …

A few anti‐amyloid trials offer a slight possibility of preventing progression of cognitive loss,
but none has reversed the process. A possible reason is that amyloid may be necessary but …

Neurodegenerative diseases have been a weighty problem in elder people who might be
stricken with motor or/and cognition defects with lower life quality urging for effective …

Aging affects almost all the aspects of brain functions, but the mechanisms remain largely
undefined. Increasing number of literatures have manifested the important role of glial cells …

Abnormalities in myelination are associated to behavioral and cognitive dysfunction in
neurodevelopmental psychiatric disorders. Thus, therapies to promote or accelerate …

Alzheimer’s risk variant APOE4 linked to myelin-assembly malfunction Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for …