Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

Background: Prevalence and impact of thiopurine S-methyltransferase (TPMT) and Nudix
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …

Background: Crigler-Najjar syndrome (CNS, OMIM: 218800) is the paradigm of an inborn
error of metabolism and a rare genetic disease with an estimated incidence of 0.6–1.0 per …

Purpose Imatinib mesylate is presently the first-line treatment for chronic myeloid leukemia
(CML). Therapeutic drug monitoring (TDM) and pharmacogenetic screening is warranted for …

Background Thiopurine methyltransferase (TPMT) enzyme plays a key role in the
metabolism of azathioprine/6-mercaptopurine (6-MP). Mutations in the enzyme lead to …

BACKGROUND: Genetic variation in the vitamin K epoxide reductase complex (VKORC1)
and cytochrome P450 4F2 (CYP4F2) genes were found to be strongly associated with the …

Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in
children. 6-mercaptopurine (6-MP) and methotrexate are backbone drugs for maintenance …

Objective: To study the genetic variation and haplotype structure of Vitamin K epoxide
reductase complex, subunit 1 (VKORC1) gene in the Tamilian population. Materials And …

Objective The MDR1 gene encodes for P-glycoprotein (P-gp), which is an efflux transporter
at the cell membrane. The P-gp has wide substrate specificity for multiple medications …

CYP19A1 gene product aromatase (CYP19A1) is a 58-kDa protein and belongs to the
member of the cytochrome P450 superfamily, which facilitates the bioconversion of …