Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondria are believed to have originated through an ancient endosymbiotic process in
which proteobacteria were captured and co-opted for energy production and cellular …

The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Esophageal squamous-cell carcinoma (ESCC) develops through multistage epithelial
cancer formation, ie, from normal epithelium, low-and high-grade intraepithelial neoplasia to …

Beyond their well-known functions in the acute phases of the immune response, neutrophils
play important roles in the various phases of tumor initiation and progression, through the …

Clearance of cellular debris is required to maintain the homeostasis of multicellular
organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration …

Living systems use proximity to regulate biochemical processes. Inspired by this
phenomenon, bifunctional modalities that induce proximity have been developed to redirect …

The formylpeptide receptors (FPRs) mediate pattern recognition of formylated peptides
derived from invading pathogens or mitochondria from dead host cells. They can also sense …

Tuft cells are a type of intestinal epithelial cells that exist in epithelial barriers and play a
critical role in immunity against parasite infection. It remains insufficiently clear whether Tuft …