Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

In just a few years, microarrays have gone from obscurity to being almost ubiquitous in
biological research. At the same time, the statistical methodology for microarray analysis has …

To date, mass spectrometry (MS) data remain inherently biased as a result of reasons
ranging from sample handling to differences caused by the instrumentation. Normalization is …

Motivation: When running experiments that involve multiple high density oligonucleotide
arrays, it is important to remove sources of variation between arrays of non-biological origin …

Non-biological experimental variation or “batch effects" are commonly observed across
multiple batches of microarray experiments, often rendering the task of combining data from …

A fundamental challenge in the post-genome era is to understand and annotate the
consequences of genetic variation, particularly within the context of human tissues. We …

Microarray analysis of multiple sclerosis (MS) lesions obtained at autopsy revealed
increased transcripts of genes encoding inflammatory cytokines, particularly interleukin-6 …

Much attention has focused on a small set of transcription factors that maintain human or
mouse embryonic stem (ES) cells in a pluripotent state. To gain a more complete …

Protein acetylation, especially histone acetylation, is the subject of both research and clinical
investigation. At least four small-molecule histone deacetylase inhibitors are currently in …

Previous studies in hepatitis B virus (HBV)-infected humans and chimpanzees suggest that
control of HBV infection involves the cells, effector functions, and molecular mediators of the …