The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Intercellular communication in the central nervous system (CNS) is essential for brain
growth, development, and homeostasis maintenance and, when dysfunctional, is involved in …

Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

Extracellular vesicles (EVs) are small bilipid layer-enclosed vesicles that can be secreted by
all tested types of brain cells. Being a key intercellular communicator, EVs have emerged as …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron (MN) disease. Its primary
cause remains elusive, although a combination of different causal factors cannot be ruled …

Acute ischemic stroke (AIS) is a global cerebrovascular disease with high disability and
mortality, which has no effective therapy. Studies have demonstrated that astrocyte-derived …

Astrocyte-derived extracellular vesicles (ADEs) allow the in vivo probing of the inflammatory
status of astrocytes practical. Serum sample and ADEs were used to test the inflammatory …

Recent studies suggest that astrocytes released a great quantity of EVs (AEVs) to
communicate with other brain cells. Under pathological conditions, AEVs are widely …

Neuroinflammation is a common pathological feature of amyotrophic lateral sclerosis (ALS).
Although scientific evidence to date does not allow defining neuroinflammation as an ALS …