Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity
Antimicrobial host defense peptides (HDPs) are a critical component of the innate immunity
with microbicidal, endotoxin-neutralizing, and immunostimulatory properties. HDPs kill …
with microbicidal, endotoxin-neutralizing, and immunostimulatory properties. HDPs kill …
Antimicrobial characterization of human β-defensin 3 derivatives
DM Hoover, Z Wu, K Tucker, W Lu… - Antimicrobial agents …, 2003 - Am Soc Microbiol
ABSTRACT Human β-defensin 3 (hBD3) is a highly basic 45-amino-acid protein that acts
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …
both as an antimicrobial agent and as a chemoattractant molecule. Although the nature of its …
Structure− activity relation of human β-defensin 3: influence of disulfide bonds and cysteine substitution on antimicrobial activity and cytotoxicity
E Klüver, S Schulz-Maronde, S Scheid, B Meyer… - Biochemistry, 2005 - ACS Publications
Human β-defensins form a group of cysteine-rich antimicrobial peptides which have been
found in epithelial tissue and, more recently, in the male genital tract. They play a role in the …
found in epithelial tissue and, more recently, in the male genital tract. They play a role in the …
Structure–activity relationships in β‐defensin peptides
K Taylor, PE Barran, JR Dorin - Peptide Science, 2008 - Wiley Online Library
The β‐defensins comprise a large family of small cationic antimicrobial peptides widely
distributed in plants, mammals and insects. These cysteine rich peptides display …
distributed in plants, mammals and insects. These cysteine rich peptides display …
Porcine β-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria
EJA Veldhuizen, M Rijnders, EA Claassen… - Molecular …, 2008 - Elsevier
Defensins are small antimicrobial peptides that play an important role in the innate immune
system of mammals. Here, we describe the antimicrobial activity of pBD-2, a recently …
system of mammals. Here, we describe the antimicrobial activity of pBD-2, a recently …
Functional analysis of the α-defensin disulfide array in mouse cryptdin-4
A Maemoto, X Qu, KJ Rosengren, H Tanabe… - Journal of Biological …, 2004 - ASBMB
The α-defensin antimicrobial peptide family is defined by a unique tridisulfide array. To test
whether this invariant structural feature determines α-defensin bactericidal activity, mouse …
whether this invariant structural feature determines α-defensin bactericidal activity, mouse …
Antimicrobial potentials and structural disorder of human and animal defensins
EH Mattar, HA Almehdar, HA Yacoub… - Cytokine & growth factor …, 2016 - Elsevier
Defensins are moonlighting peptides which are broadly distributed throughout all the living
kingdoms. They play a multitude of important roles in human health and disease …
kingdoms. They play a multitude of important roles in human health and disease …
The androgen-regulated epididymal sperm-binding protein, human β-defensin 118 (DEFB118)(formerly ESC42), is an antimicrobial β-defensin
Spermatozoa bind a variety of proteins as they pass through the proximal regions of the
epididymis, where they acquire forward motility and fertilizing ability. Recent evidence …
epididymis, where they acquire forward motility and fertilizing ability. Recent evidence …
Antifungal activities of human beta-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3
V Krishnakumari, N Rangaraj… - Antimicrobial agents and …, 2009 - Am Soc Microbiol
The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1,
Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower …
Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower …