Beyond statins: New pharmacological targets to decrease LDL-cholesterol and cardiovascular events
E Raschi, M Casula, AFG Cicero, A Corsini… - Pharmacology & …, 2023 - Elsevier
The pharmacological treatment of dyslipidemia, a major modifiable risk factor for developing
atherosclerotic cardiovascular disease (ASCVD), remains a debated and controversial …
atherosclerotic cardiovascular disease (ASCVD), remains a debated and controversial …
Long-Term efficacy and tolerability of PCSK9 targeted therapy: a review of the literature
WAM Schonck, ESG Stroes, GK Hovingh… - Drugs, 2024 - Springer
Increased plasma levels of low-density lipoprotein cholesterol (LDL-C) are causally
associated with atherosclerotic cardiovascular disease (ASCVD), and statins that lower LDL …
associated with atherosclerotic cardiovascular disease (ASCVD), and statins that lower LDL …
PCSK9 inhibitors for secondary prevention in patients with cardiovascular diseases: a bayesian network meta-analysis
X Wang, D Wen, Y Chen, L Ma, C You - Cardiovascular diabetology, 2022 - Springer
Abstract Background The Food and Drug Administration has approved Proprotein
Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors for the treatment of dyslipidemia …
Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors for the treatment of dyslipidemia …
Optimal implementation of the 2019 ESC/EAS dyslipidaemia guidelines in patients with and without atherosclerotic cardiovascular disease across Europe: A …
J Brandts, S Bray, G Villa, AL Catapano… - The Lancet Regional …, 2023 - thelancet.com
Background The impact of the stepwise implementation of the 2019 European Society of
Cardiology (ESC)/European Atherosclerosis Society (EAS) treatment algorithm on low …
Cardiology (ESC)/European Atherosclerosis Society (EAS) treatment algorithm on low …
[HTML][HTML] Long-term persistence with evolocumab treatment and sustained reductions in LDL-cholesterol levels over 30 months: final results from the European …
KK Ray, E Bruckert, P Peronne-Filardi, C Ebenbichler… - Atherosclerosis, 2023 - Elsevier
Background and aims Variability in low-density lipoprotein-cholesterol (LDL-C) level control
at a population level is associated with poor cardiovascular outcomes. Limited data exist on …
at a population level is associated with poor cardiovascular outcomes. Limited data exist on …
[HTML][HTML] Efficacy, safety, adherence and persistence of PCSK9 inhibitors in clinical practice: A single country, multicenter, observational study (AT-TARGET-IT)
Abstract Background and aims Proprotein Convertase Subtilisin/Kexin type 9 inhibitors
(PCSK9i) are recommended in patients at high and very-high cardiovascular (CV) risk, with …
(PCSK9i) are recommended in patients at high and very-high cardiovascular (CV) risk, with …
Multizonal observational study conducted by clinical practitioners on evolocumab use in subjects with hyperlipidemia in Saudi Arabia and Kuwait: Results from the …
K Al Faraidy, M Akbar, M Shehri, M Aljarallah… - PLoS …, 2023 - journals.plos.org
Objectives Dyslipidemia is a prevalent condition with significant morbidity and mortality
across the world, including in the Arabian Gulf. The present study aimed to describe the …
across the world, including in the Arabian Gulf. The present study aimed to describe the …
Guideline LDL-C threshold achievement in acute myocardial infarction patients: a real-world evidence study demonstrating the impact of treatment intensification with …
ES Mackinnon, B Har, S Champsi, RJ Wani… - Cardiology and …, 2023 - Springer
Introduction A high proportion of Canadian patients with acute myocardial infarction (AMI) do
not achieve the threshold low-density lipoprotein cholesterol (LDL-C) levels recommended …
not achieve the threshold low-density lipoprotein cholesterol (LDL-C) levels recommended …
Evolocumab-Based LDL-C Management in High and Very High Cardiovascular Risk Patients in German Clinical Practice: The HEYMANS Study
M Lehrke, A Vogt, V Schettler, M Girndt, U Fraass… - Advances in …, 2024 - Springer
Introduction Low-density lipoprotein cholesterol (LDL-C) is among the most important
modifiable risk factors for cardiovascular disease. In very high-risk patients, the European …
modifiable risk factors for cardiovascular disease. In very high-risk patients, the European …
Real-World Insights into Evolocumab Use in Patients with Hyperlipidemia Across Five Countries: Analysis from the ZERBINI Study
Introduction This study characterizes patients receiving evolocumab in clinical practice and
assesses treatment effectiveness, safety and persistence outcomes across five countries …
assesses treatment effectiveness, safety and persistence outcomes across five countries …