[HTML][HTML] Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity

AC Ferreira, BM Hemmer, SM Philippi… - Molecular …, 2023 - nature.com
Functional output of the hippocampus, a brain region subserving memory function, depends
on highly orchestrated cellular and molecular processes that regulate synaptic plasticity …

Engineering the physical microenvironment into neural organoids for neurogenesis and neurodevelopment

M Li, H Sun, Z Hou, S Hao, L Jin, B Wang - Small, 2024 - Wiley Online Library
Understanding the signals from the physical microenvironment is critical for deciphering the
processes of neurogenesis and neurodevelopment. The discovery of how surrounding …

Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues

C Handler, C Testi, G Scarcelli - Current Opinion in Cell Biology, 2024 - Elsevier
Recent research has highlighted the growing significance of the mechanical properties of
cells and tissues in the proper execution of physiological functions within an organism; …

[HTML][HTML] Insights in cell biomechanics through atomic force microscopy

S Kerdegari, P Canepa, D Odino, R Oropesa-Nuñez… - Materials, 2023 - mdpi.com
We review the advances obtained by using Atomic Force Microscopy (AFM)-based
approaches in the field of cell/tissue mechanics and adhesion, comparing the solutions …

Brain stiffness follows cuprizone-induced variations in local myelin content

X Zhang, J Weickenmeier - Acta Biomaterialia, 2023 - Elsevier
Brain maturation and neurological diseases are intricately linked to microstructural changes
that inherently affect the brain's mechanical behavior. Animal models are frequently used to …

[HTML][HTML] Matrix stiffness-dependent microglia activation in response to inflammatory cues: in situ investigation by scanning electrochemical microscopy

Y Liu, J Zhang, Y Li, Y Zhao, S Kuermanbayi… - Chemical …, 2024 - pubs.rsc.org
Microglia play a crucial role in maintaining the homeostasis of the central nervous system
(CNS) by sensing and responding to mechanical and inflammatory cues in their …

[HTML][HTML] Functional characterization of mechanosensitive piezo1 channels in trigeminal and somatic nerves in a neuron-on-chip model

N Mikhailov, L Plotnikova, P Singh… - International Journal of …, 2022 - mdpi.com
Mechanosensitive ion channels, Piezo1 and 2, are activated by pressure and involved in
diverse physiological functions, including senses of touch and pain, proprioception and …

[HTML][HTML] Mechanotransduction: exploring new therapeutic avenues in central nervous system pathology

DN Rocha, ED Carvalho, JB Relvas… - Frontiers in …, 2022 - frontiersin.org
Cells are continuously exposed to physical forces and the central nervous system (CNS) is
no exception. Cells dynamically adapt their behavior and remodel the surrounding …

Superviscous properties of the in vivo brain at large scales

H Herthum, SCH Dempsey, A Samani, F Schrank… - Acta biomaterialia, 2021 - Elsevier
There is growing awareness that brain mechanical properties are important for neural
development and health. However, published values of brain stiffness differ by orders of …

[HTML][HTML] Microenvironments matter: advances in brain-on-chip

G Akcay, R Luttge - Biosensors, 2023 - mdpi.com
To highlight the particular needs with respect to modeling the unique and complex
organization of the human brain structure, we reviewed the state-of-the-art in devising brain …