[HTML][HTML] Neuronal TIMP2 regulates hippocampus-dependent plasticity and extracellular matrix complexity
Functional output of the hippocampus, a brain region subserving memory function, depends
on highly orchestrated cellular and molecular processes that regulate synaptic plasticity …
on highly orchestrated cellular and molecular processes that regulate synaptic plasticity …
Engineering the physical microenvironment into neural organoids for neurogenesis and neurodevelopment
Understanding the signals from the physical microenvironment is critical for deciphering the
processes of neurogenesis and neurodevelopment. The discovery of how surrounding …
processes of neurogenesis and neurodevelopment. The discovery of how surrounding …
Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues
C Handler, C Testi, G Scarcelli - Current Opinion in Cell Biology, 2024 - Elsevier
Recent research has highlighted the growing significance of the mechanical properties of
cells and tissues in the proper execution of physiological functions within an organism; …
cells and tissues in the proper execution of physiological functions within an organism; …
[HTML][HTML] Insights in cell biomechanics through atomic force microscopy
S Kerdegari, P Canepa, D Odino, R Oropesa-Nuñez… - Materials, 2023 - mdpi.com
We review the advances obtained by using Atomic Force Microscopy (AFM)-based
approaches in the field of cell/tissue mechanics and adhesion, comparing the solutions …
approaches in the field of cell/tissue mechanics and adhesion, comparing the solutions …
Brain stiffness follows cuprizone-induced variations in local myelin content
X Zhang, J Weickenmeier - Acta Biomaterialia, 2023 - Elsevier
Brain maturation and neurological diseases are intricately linked to microstructural changes
that inherently affect the brain's mechanical behavior. Animal models are frequently used to …
that inherently affect the brain's mechanical behavior. Animal models are frequently used to …
[HTML][HTML] Matrix stiffness-dependent microglia activation in response to inflammatory cues: in situ investigation by scanning electrochemical microscopy
Y Liu, J Zhang, Y Li, Y Zhao, S Kuermanbayi… - Chemical …, 2024 - pubs.rsc.org
Microglia play a crucial role in maintaining the homeostasis of the central nervous system
(CNS) by sensing and responding to mechanical and inflammatory cues in their …
(CNS) by sensing and responding to mechanical and inflammatory cues in their …
[HTML][HTML] Functional characterization of mechanosensitive piezo1 channels in trigeminal and somatic nerves in a neuron-on-chip model
N Mikhailov, L Plotnikova, P Singh… - International Journal of …, 2022 - mdpi.com
Mechanosensitive ion channels, Piezo1 and 2, are activated by pressure and involved in
diverse physiological functions, including senses of touch and pain, proprioception and …
diverse physiological functions, including senses of touch and pain, proprioception and …
[HTML][HTML] Mechanotransduction: exploring new therapeutic avenues in central nervous system pathology
DN Rocha, ED Carvalho, JB Relvas… - Frontiers in …, 2022 - frontiersin.org
Cells are continuously exposed to physical forces and the central nervous system (CNS) is
no exception. Cells dynamically adapt their behavior and remodel the surrounding …
no exception. Cells dynamically adapt their behavior and remodel the surrounding …
Superviscous properties of the in vivo brain at large scales
There is growing awareness that brain mechanical properties are important for neural
development and health. However, published values of brain stiffness differ by orders of …
development and health. However, published values of brain stiffness differ by orders of …
[HTML][HTML] Microenvironments matter: advances in brain-on-chip
G Akcay, R Luttge - Biosensors, 2023 - mdpi.com
To highlight the particular needs with respect to modeling the unique and complex
organization of the human brain structure, we reviewed the state-of-the-art in devising brain …
organization of the human brain structure, we reviewed the state-of-the-art in devising brain …