The activation of microglia, the inflammatory cells of the central nervous system (CNS), has
been linked to the pathogenesis of Alzheimer's disease and other neurodegenerative …

Background Aging and dementia involve the disruption of brain molecular pathways leading
to the alterations in tissue composition and gross morphology of the brain. Phenotypic and …

Large vesicle extrusion from neurons may contribute to spreading pathogenic protein
aggregates and promoting inflammatory responses, two mechanisms leading to …

In this review, we shed light on recent advances regarding the characterization of
biochemical pathways of cellular mechanosensing and mechanotransduction with particular …

The question of whether material stiffness enhances cell adhesion and clustering is still
open to debate. Results from the literature are seemingly contradictory, with some reports …

Astrocytes, highly specialized glial cells, play a critical role in neuronal function. Variations in
brain extracellular matrix (ECM) during development and disease can significantly alter …

The FERM domain-containing protein 6 (FRMD6), also known as Willin, is an upstream
regulator of Hippo signaling that has recently been shown to modulate actin cytoskeleton …

Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …

In this study, we developed a novel type of dibenzocyclooctyne (DBCO)‐functionalized
microbubbles (MBs) and validated their attachment to azide‐labelled sialoglycans on …

Stem cell‐derived 3D tissues such as spheroids are excellent models for investigating
mechanisms of tissue formation and responses to physiological and mechanical cues …