G9a and EZH2 are two histone methyltransferases commonly upregulated in several cancer
types, yet the precise roles that these enzymes play cooperatively in cancer is unclear. We …

ABSTRACT Introduction: MDA-7/Interleukin-24 (IL-24), as a pleiotropic cytokine, exhibits a
specific tumor suppression property that has attracted a great deal of attention. While its anti …

Interleukin 24 (IL-24) is a tumor-suppressing protein, which inhibits angiogenesis and
induces cancer cell-specific apoptosis. We have shown that IL-24 regulates apoptosis …

Glaucoma is a heterogeneous group of optic neuropathies characterized by a progressive
degeneration of the retinal ganglion cells (RGCs), leading to irreversible vision loss …

We found that pediatric glioblastomas (PED-GBM) cell lines from diffuse intrinsic pontine
glioma (DIPG) carrying the H3K27M mutation or from diffuse hemispheric glioma expressing …

The second-leading cause of death, cancer, poses a significant threat to human life.
Innovations in cancer therapies are crucial due to limitations in traditional approaches …

Background Exposure to air pollution exerts direct effects on respiratory organs; however,
molecular alterations underlying air pollution-induced pulmonary injury remain unclear. In …

Hepatocyte nuclear factor 4 α (HNF4α) is an important transcription factor that acts as a pro-
proliferative mediator during tumorigenesis, yet its function in colorectal cancer (CRC) …

Intestinal microbiota has emerged as an important player in the health and disease of
preterm infants. The interactions between intestinal flora and epithelium can lead to local …

Dysregulated activity of helicase eIF4A drives transformation to and maintenance of cancer
cell phenotype by reprogramming cellular translation. Interleukin 24 (IL-24) is a tumor …