Link between obesity and atopic dermatitis: Does obesity predispose to atopic dermatitis, or vice versa?

S Yang, T Zhu, JS Wakefield, TM Mauro… - Experimental …, 2023 - Wiley Online Library
Two serious health conditions, obesity and atopic dermatitis (AD), share some pathological
features such as insulin resistance, leptin resistance and inflammation, and a growing body …

Efficacy and safety of lebrikizumab in moderate-to-severe atopic dermatitis: 52-week results of two randomized double-blinded placebo-controlled phase III trials

A Blauvelt, JP Thyssen… - British Journal of …, 2023 - academic.oup.com
Background Lebrikizumab is a novel, high-affinity monoclonal antibody that selectively binds
to interleukin (IL)-13. Objectives To evaluate the efficacy and safety of lebrikizumab …

Age of onset defines two distinct profiles of atopic dermatitis in adults

P Facheris, JC Da Rosa, AD Pagan, M Angelov… - Allergy, 2023 - Wiley Online Library
Background The incidence of adult‐onset atopic dermatitis (AOAD) is increasing. However,
the unique characteristics of AOAD compared to pediatric‐onset AD persisting into …

[HTML][HTML] Immunological pathomechanisms of spongiotic dermatitis in skin lesions of atopic dermatitis

R Tanei, Y Hasegawa - International Journal of Molecular Sciences, 2022 - mdpi.com
Atopic dermatitis (AD) is a chronic pruritic skin disease with a complex pathogenesis
underlying its heterogeneous clinical phenotypes and endotypes. The skin manifestation of …

[HTML][HTML] The role of oxidative stress in atopic dermatitis and chronic urticaria

S Galiniak, M Mołoń, M Biesiadecki, A Bożek, M Rachel - Antioxidants, 2022 - mdpi.com
Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an
increasing prevalence and pathogenesis that are not fully understood. Emerging evidence …

Safety and efficacy of tralokinumab in older adults with moderate-to-severe atopic dermatitis: a secondary analysis

JF Merola, DC Butler, T Mark, S Schneider… - JAMA …, 2023 - jamanetwork.com
Importance Older adults with atopic dermatitis (AD) face unique treatment challenges,
including comorbidities, polypharmacy, and a higher risk for infections (eg, herpes zoster) …

[HTML][HTML] Association between hidradenitis suppurativa and atopic diseases: a multi-center, propensity-score-matched cohort study

HC Chang, CY Lin, YC Guo, HY Lu… - … Journal of Medical …, 2024 - ncbi.nlm.nih.gov
Background: Cross-sectional evidence has suggested a high prevalence of atopic diseases
in patients with hidradenitis suppurativa (HS). However, there is a lack of evidence based on …

[HTML][HTML] Efficacy and safety of dupilumab maintained in adults≥ 60 years of age with moderate-to-severe atopic dermatitis: analysis of pooled data from four …

JI Silverberg, CW Lynde, K Abuabara… - American journal of …, 2023 - Springer
Background Adults aged≥ 60 years are often underrepresented in atopic dermatitis (AD)
clinical trials; age-related comorbidities may impact treatment efficacy and safety. Objective …

Atopic dermatitis across the life course

K Abuabara, SM Langan - British Journal of Dermatology, 2023 - academic.oup.com
Atopic dermatitis, the most common chronic inflammatory skin disease, can occur at any
age, and patterns of disease activity vary over time. Both prevalence and incidence are …

[HTML][HTML] Age-dependent distribution of atopic dermatitis in primary care: a nationwide population-based study from Finland

A Salava, R Rieppo, A Lauerma… - Acta Dermato …, 2022 - ncbi.nlm.nih.gov
The burden of atopic dermatitis (AD) appears to be increasing in adult and elderly patients.
The aim of this study was to analyse the nationwide database of the Finnish Institute for …