Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Gene therapy is on its way to revolutionize the treatment of both inherited and acquired
diseases, by transferring nucleic acids to correct a disease-causing gene in the target cells …

Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …

The cell-free DNA (cfDNA) levels are known to increase in biological fluids in various
pathological conditions. However, the data on circulating cfDNA in severe psychiatric …

Type I and III interferons (IFNs) are essential for antiviral immunity and act through two
different but complimentary pathways. First, IFNs activate intracellular antimicrobial …

Aptamers have great potential for diagnostics and therapeutics due to high specificity to
target molecules. However, studies have shown that aptamers are rapidly distributed and …

Cellular senescence is believed to contribute to aging and disease through the activity of
secreted factors that promote inflammation, remodel the extracellular matrix, and adversely …

As the first barrier of host defense, innate immunity sets up the parclose to keep out external
microbial or virus attacks. Depending on the type of pathogens, several cytoplasm pattern …

There is mounting evidence that the development of Alzheimer's disease (AD) interacts
extensively with immunological processes in the brain and extends beyond the neuronal …