Epidemiological and clinical studies suggest that non-steroidal anti-inflammatory drugs
(NSAIDs), including cyclooxygenase (COX)-2 selective inhibitors, reduce the risk of …

Aspirin inhibits the enzyme cyclooxygenase (Cox), and there is a significant body of
epidemiological evidence demonstrating that regular aspirin use is associated with a …

Nonsteroidal anti-inflammatory drugs, which inhibit cyclooxygenase (COX) activity, are
powerful antineoplastic agents that exert their antiproliferative and proapoptotic effects on …

Colorectal cancer is a major cause of mortality and whilst up to 80% of sporadic colorectal
tumours are considered preventable, trends toward increasing obesity suggest the potential …

Chronic inflammation is strongly associated with approximately 1/5th of all human cancers.
Arising from combinations of factors such as environmental exposures, diet, inherited gene …

Cancer is a leading cause of death worldwide. The expression of COX-2 and prostaglandins
has not only been associated with various types of cancer but is also directly proportional to …

Experimental studies have shown that β-carotene inhibited the growth of colon cancer cells,
and human trials have demonstrated that the carotenoid reduces colon cell proliferation of …

Nonsteroidal antiinflammatory drugs (NSAIDs) can prevent colorectal tumorigenesis in
humans and in rodents. In vitro and in vivo studies indicate that one of their principal …

There is compelling evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and
cyclooxygenase-2 selective inhibitors have antineoplastic activity, but toxicity from …

Epidemiological, clinical, animal and laboratory studies have all provided evidence for the
protective effects of non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, against …