Current and future antiplatelet therapies: emphasis on preserving haemostasis

JD McFadyen, M Schaff, K Peter - Nature Reviews Cardiology, 2018 - nature.com
Antiplatelet drugs, such as aspirin, P2Y12 antagonists, and glycoprotein (GP) IIb/IIIa
inhibitors, have proved to be successful in reducing the morbidity and mortality associated …

Integrins as therapeutic targets: lessons and opportunities

D Cox, M Brennan, N Moran - Nature reviews Drug discovery, 2010 - nature.com
The integrins are a large family of cell adhesion molecules that are essential for the
regulation of cell growth and function. The identification of key roles for integrins in a diverse …

Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: a …

PG Steg, S James, RA Harrington, D Ardissino… - Circulation, 2010 - Am Heart Assoc
Background—Aspirin and clopidogrel are recommended for patients with acute coronary
syndromes (ACS) or undergoing coronary stenting. Ticagrelor, a reversible oral P2Y12 …

Antiplatelet agents for the treatment and prevention of atherothrombosis

C Patrono, F Andreotti, H Arnesen… - European heart …, 2011 - academic.oup.com
The clinical pharmacology of antiplatelet drugs has been reviewed previously by the
European Society of Cardiology (ESC) Task force and by the 8th American College of Chest …

The causal role of megakaryocyte–platelet hyperactivity in acute coronary syndromes

JF Martin, SD Kristensen, A Mathur, EL Grove… - Nature Reviews …, 2012 - nature.com
Platelets are causally involved in coronary artery obstruction in acute coronary syndromes
(ACS). This cell type is unique to mammals and its production, which is unlike that of any …

αvβ3‐or α5β1‐integrin‐selective peptidomimetics for surface coating

C Mas‐Moruno, R Fraioli… - Angewandte Chemie …, 2016 - Wiley Online Library
Engineering biomaterials with integrin‐binding activity is a very powerful approach to
promote cell adhesion, modulate cell behavior, and induce specific biological responses at …

" Venomous" Bites from" non-venomous" Snakes

SA Weinstein, DA Warrell, DE Keyler - 2022 - books.google.com
" Venomous" Bites from" Non-Venomous" Snakes, Second Edition thoroughly examines the
potential hazards associated with bites by non-front-fanged snakes (popularly, but …

Lipoproteins as modulators of atherothrombosis: from endothelial function to primary and secondary coagulation

AB Ouweneel, M Van Eck - Vascular pharmacology, 2016 - Elsevier
Atherothrombosis is a complication of atherosclerosis that causes acute cardiovascular
events such as myocardial infarction and stroke. Circulating lipid levels are highly correlated …

Updates to the ACCF/AHA and ESC STEMI and NSTEMI guidelines: putting guidelines into clinical practice

JD Wessler, J Stant, S Duru, LR Rabbani… - American Journal of …, 2015 - ajconline.org
The publication of consensus group guidelines provides an opportunity to standardize
practices through evidence-based protocols. Variations in patient care have been shown to …

Optimal P2Y12 Inhibitor in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Network Meta …

AM Rafique, P Nayyar, TY Wang, R Mehran… - JACC: Cardiovascular …, 2016 - jacc.org
Objectives: The study sought to compare the clinical efficacy and safety of P2Y12 inhibitors
in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary …