Adipokines are cell-signaling proteins secreted by adipose tissue that has been related to a
low-grade state of inflammation and different pathologies. The present review aims to …

Background Obesity develops due to an imbalance in energy homeostasis, wherein energy
intake exceeds energy expenditure. Accumulating evidence shows that manipulations of …

The ability of the body to maintain homeostasis requires constant communication between
the brain and peripheral tissues. Different organs produce signals, often in the form of …

Autophagy represents a key regulator of aging and metabolism in sensing energy
deprivation. We find that fasting in mice activates autophagy in the liver paralleled by …

Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …

Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

Hypothalamic gliosis associated with high-fat diet (HFD) feeding increases susceptibility to
hyperphagia and weight gain. However, the body-weight-independent contribution of …

Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

The 21st century is characterized by an increasing incidence and prevalence of obesity and
the burden of its associated comorbidities, especially cardiometabolic diseases, which are …

Eating behaviours are determined by the integration of interoceptive and environmental
inputs. During pregnancy, numerous physiological adaptations take place in the maternal …