Neuron–glia interactions play a key role in maintaining and regulating the central nervous
system. Glial cells are implicated in the function of dopamine neurons and regulate their …

Retinal neurodegenerative disease involves an inflammatory response in the retina
characterized by an increase in inflammatory cytokines and activation of microglia. The …

Activated microglia have been proposed to play a major role in the pathogenesis of
Huntington's Disease (HD). PK11195 is a ligand which binds selectively to peripheral …

The muscular dystrophies are a heterogeneous group of disorders for which there are
currently no cures. Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant …

Alzheimer's disease (AD) is characterized by the presence of neurofibrillary tangles of
hyperphosphorylated, aggregated tau protein and extracellular deposits of β‐amyloid …

Minocycline is a member of the tetracycline class of molecules with broad-spectrum
antibiotic activity. The unique properties of minocycline result in increased tissue distribution …

Mechanisms of tissue damage in Huntington's disease involve excitotoxicity, mitochondrial
damage, and inflammation, including microglia activation. Immunomodulatory and anti …

The use of tetracyclines has declined because of the appearance of resistant bacterial
strains. However, the indications of nonantimicrobial activities of these drugs have …

Release of mitochondrial cytochrome c resulting in downstream activation of cell death
pathways has been suggested to play a role in neurologic diseases featuring cell death …

Ataxin-3 is a ubiquitously expressed deubiqutinating enzyme with important functions in the
proteasomal protein degradation pathway and regulation of transcription. The C-terminus of …