Huntington's disease is a neurodegenerative disorder resulting from expansion of a
polyglutamine tract in the Huntingtin protein. Mutant Huntingtin forms intracellular …

The magnitude of the risk of prostate cancer among Ashkenazi Jewish carriers of the
common mutations in the BRCA1 and BRCA2 genes, the so-called Ashkenazi BRCA …

This study assessed the futility of proceeding with a Phase 3 clinical trial of minocycline as a
disease‐modifying treatment for Huntington's disease (HD). One hundred fourteen research …

Minocycline, a derivative of the antibiotic tetracycline, displays neuroprotective properties in
various models of neurodegenerative diseases and is now used in clinical trials, because of …

Minocycline exerts beneficial immune modulatory effects in several noninfectious
neurodegenerative disease models; however, its potential to influence the host immune …

Modulation of immune activation using immunotherapy has attracted considerable attention
for many years as a potential therapeutic intervention for several inflammation-associated …

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an
expanded CAG repeat in the HD gene that results in cortical and striatal degeneration, and …

Minocycline has been shown to alleviate several neurological disorders. Unexpectedly, we
found that minocycline had opposite effects on glioma cells: minocycline induced …

Huntington's disease (HD) is a devastating neuropsychiatric disorder for which therapeutic
interventions have been rather fruitless to date, except in a slight symptomatic relief. Even …

Protein aggregation and subsequent accumulation of insoluble amyloid fibrils with cross-β
structure is an intrinsic characteristic of amyloid diseases, ie, amyloidoses. Amyloid …