J. Neurochem.(2011) 116, 273–280. Abstract An interaction between adenosine A2A
receptors (A2ARs) and cannabinoid CB1 receptors (CB1Rs) has been consistently reported …

Medium spiny neurons (MSNs) expressing dopamine D1 receptor (D1R) or D2 receptor
(D2R) are major components of the striatum. Stimulation of D1R activates protein kinase A …

Attention deficit and hyperactivity disorder (ADHD) is characterized by impaired levels of
hyperactivity, impulsivity, and inattention. Adenosine and endocannabinoid systems tightly …

The mechanism of propofol‐anesthesia‐induced loss of consciousness (LOC) remains
largely unknown. We speculated that the adenosine A2A receptor serves as a vital …

Nucleoside receptors are known to be important targets for a variety of brain diseases.
However, the therapeutic modulation of their endogenous agonists by inhibitors of …

Parkinson's disease (PD) is the second most common neurodegenerative disorder,
characterized by progressive loss of dopaminergic neurons that results in characteristic …

Aim: Levodopa is first line treatment of Parkinson's disease (PD). However, its use is
associated with the presence of motor fluctuations and dyskinesias. In recent years …

Recent research is leading to an ever-increasing range of investigative approaches whose
aim is to achieve effective neuroprotective or neurorestorative treatment for individuals …

Animals remember temporal links between their actions and subsequent rewards. We
previously discovered a synaptic mechanism underlying such reward learning in D1 …

Huntington's (HD) and Parkinson's diseases (PD) are neurodegenerative disorders caused
by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to …