Endogenous adenosine is a widely distributed upstream regulator of a broad spectrum of
neurotransmitters, receptors, and signaling pathways that converge to contribute to the …

The central adenosine system and adenosine receptors play a fundamental role in the
modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co …

Mental fatigue impairs both cognitive and physical performance. Bioactive substances (eg,
caffeine) have been used to counteract mental fatigue but could have side effects. The …

[Frontiers in Bioscience 13, 2391-2399, January 1, 2008] 2391 Adenosine A1-A2A receptor
heteromers: new targets for caffeine in Page 1 [Frontiers in Bioscience 13, 2391-2399, January …

Adenosine and endocannabinoids are very ubiquitous non‐classical neurotransmitters that
exert a modulatory role on the transmission of other more 'classical'neurotransmitters. In this …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, characterized by symptoms of bradykinesia, rigidity, postural instability, and …

Psychiatric disorders describe different mental or behavioral patterns, causing suffering or
poor coping of ordinary life with manifold presentations. Multifactorial processes can …

Extracellular ATP can be a danger signal, but its role in striatal circuits afflicted in
Parkinson's disease (PD) is unclear and was now investigated. ATP was particularly …

The function of striatal adenosine A 2A receptors (A 2A Rs) is well recognized because of
their high expression levels and the documented antagonistic interaction between A 2A Rs …

Astrocytic glutamate transporter-1 (GLT-I) is critical to control the bulk of glutamate uptake
and, thus, to regulate synaptic plasticity and excitotoxicity. GLT-I glutamate uptake is driven …