OGEE is an Online GEne Essentiality database. Its main purpose is to enhance our
understanding of the essentiality of genes. This is achieved by collecting not only …

Here, we review the'target-centric'genomic strategy to antimicrobial discovery and share our
perspective on identification, validation and prioritization of potential antimicrobial drug …

Monothiol glutaredoxins with the CGFS sequence at the active site are widespread among
prokaryotes and eukaryotes. Two subclasses exist, those with a single glutaredoxin domain …

Commensal and pathogenic bacteria must deal with many different stress conditions to
survive in and colonize the human gastrointestinal tract. One major challenge that bacteria …

In their role as primary producers, marine phytoplankton modulate heterotrophic bacterial
activities through differences in the types and amounts of organic matter they release. This …

Operons are a major feature of all prokaryotic genomes, but how and why operon structures
vary is not well understood. To elucidate the life-cycle of operons, we compared gene order …

Understanding the extreme variation among bacterial genomes remains an unsolved
challenge in evolutionary biology, despite long-standing debate about the relative …

For many bacteria with sequenced genomes, we do not understand how they synthesize
some amino acids. This makes it challenging to reconstruct their metabolism, and has led to …

Large-scale rearrangements may be important in evolution because they can alter
chromosome organization and gene expression in ways not possible through point …

The constraint-based analysis of genome-scale metabolic and regulatory networks has
been successful in predicting phenotypes and useful for analyzing high-throughput data …