Inhibition of lysine biosynthesis: an evolving antibiotic strategy
Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel
antibacterial agents as it provides lysine for protein synthesis and both lysine and meso …
antibacterial agents as it provides lysine for protein synthesis and both lysine and meso …
New targets and screening approaches in antimicrobial drug discovery
There is no doubt that the existing arsenal of antimicrobial agents we have in hand for the
treatment of infectious diseases is insufficient to protect us over the long term. 1-3 The …
treatment of infectious diseases is insufficient to protect us over the long term. 1-3 The …
Evidence-Based Annotation of Gene Function in Shewanella oneidensis MR-1 Using Genome-Wide Fitness Profiling across 121 Conditions
Most genes in bacteria are experimentally uncharacterized and cannot be annotated with a
specific function. Given the great diversity of bacteria and the ease of genome sequencing …
specific function. Given the great diversity of bacteria and the ease of genome sequencing …
A comparison of dense transposon insertion libraries in the Salmonella serovars Typhi and Typhimurium
L Barquist, GC Langridge, DJ Turner… - Nucleic acids …, 2013 - academic.oup.com
Abstract Salmonella Typhi and Typhimurium diverged only∼ 50 000 years ago, yet have
very different host ranges and pathogenicity. Despite the availability of multiple whole …
very different host ranges and pathogenicity. Despite the availability of multiple whole …
A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease
Recurrent bacterial infections are a significant burden worldwide, and prior history of
infection is often a significant risk factor for developing new infections. For urinary tract …
infection is often a significant risk factor for developing new infections. For urinary tract …
Operon formation is driven by co-regulation and not by horizontal gene transfer
The organization of bacterial genes into operons was originally ascribed to the benefits of co-
regulation. More recently, the “selfish operon” model, in which operons are formed by …
regulation. More recently, the “selfish operon” model, in which operons are formed by …
HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions
Y Zhang, CS Mandava, W Cao, X Li, D Zhang… - Nature structural & …, 2015 - nature.com
Adverse cellular conditions often lead to nonproductive translational stalling and arrest of
ribosomes on mRNAs. Here, we used fast kinetics and cryo-EM to characterize Escherichia …
ribosomes on mRNAs. Here, we used fast kinetics and cryo-EM to characterize Escherichia …
Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome
Lysine acetylation is a protein posttranslational modification (PTM) that occurs on thousands
of lysine residues in diverse organisms from bacteria to humans. Accurate measurement of …
of lysine residues in diverse organisms from bacteria to humans. Accurate measurement of …
Topological units of environmental signal processing in the transcriptional regulatory network of Escherichia coli
G Balazsi, AL Barabási… - Proceedings of the …, 2005 - National Acad Sciences
Recent evidence indicates that potential interactions within metabolic, protein–protein
interaction, and transcriptional regulatory networks are used differentially according to the …
interaction, and transcriptional regulatory networks are used differentially according to the …
The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide
MJ Allen, GF White, AP Morby - Microbiology, 2006 - microbiologyresearch.org
The global response of Escherichia coli to the broad-spectrum biocide polyhexamethylene
biguanide (PHMB) was investigated using transcriptional profiling. The transcriptional …
biguanide (PHMB) was investigated using transcriptional profiling. The transcriptional …