[HTML][HTML] Deep learning in cancer pathology: a new generation of clinical biomarkers

A Echle, NT Rindtorff, TJ Brinker, T Luedde… - British journal of …, 2021 - nature.com
Clinical workflows in oncology rely on predictive and prognostic molecular biomarkers.
However, the growing number of these complex biomarkers tends to increase the cost and …

[HTML][HTML] The prognostic impact of tumor mutational burden (TMB) in the first-line management of advanced non-oncogene addicted non-small-cell lung cancer …

A Galvano, V Gristina, U Malapelle, P Pisapia, F Pepe… - ESMO open, 2021 - Elsevier
Background The role of tumor mutational burden (TMB) is still debated for selecting
advanced non-oncogene addicted non-small-cell lung cancer (NSCLC) patients who might …

Prospective role and immunotherapeutic targets of sideroflexin protein family in lung adenocarcinoma: evidence from bioinformatics validation

HH Dang, HDK Ta, TTT Nguyen, G Anuraga… - Functional & Integrative …, 2022 - Springer
As lung cancer remains the leading cause of cancer deaths globally, characterizing the
tumor molecular profiles is crucial to tailoring treatments for individuals at advanced stages …

KRAS‐G12D mutation drives immune suppression and the primary resistance of anti‐PD‐1/PD‐L1 immunotherapy in non‐small cell lung cancer

C Liu, S Zheng, Z Wang, S Wang, X Wang… - Cancer …, 2022 - Wiley Online Library
Background Although immune checkpoint inhibitors (ICIs) against programmed cell death
protein 1 (PD‐1) and its ligand PD‐L1 have demonstrated potency towards treating patients …

Prussian blue/calcium peroxide nanocomposites-mediated tumor cell iron mineralization for treatment of experimental lung adenocarcinoma

K Zhang, J Wu, X Zhao, J Qin, Y Xue, W Zheng… - ACS …, 2021 - ACS Publications
Current lung cancer diagnosis methods encounter delayed visual confirmation of tumor foci
and low-resolution metrics in imaging findings, which delays the early treatment of tumors …

[HTML][HTML] Nanomedicine in lung cancer immunotherapy

M Doroudian, S Zanganeh… - … in bioengineering and …, 2023 - frontiersin.org
Lung cancer is the major cause of cancer death worldwide. Cancer immunotherapy has
been introduced as a promising and effective treatment that can improve the immune …

[HTML][HTML] Current insights into combination therapies with MAPK inhibitors and immune checkpoint blockade

MH Shin, J Kim, SA Lim, J Kim, KM Lee - International journal of …, 2020 - mdpi.com
The recent development of high-throughput genomics has revolutionized personalized
medicine by identifying key pathways and molecular targets controlling tumor progression …

[HTML][HTML] hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527

C Li, J Zhang, X Yang, C Hu, T Chu, R Zhong… - Cell death & …, 2021 - nature.com
The relationship between circular RNA (circRNA) and cancer stem cells (CSCs) is uncertain.
We have investigated the combined influence of CSCs, circRNA (hsa_circ_0003222), and …

[HTML][HTML] Nephrotoxicity as a complication of chemotherapy and immunotherapy in the treatment of colorectal cancer, melanoma and non-small cell lung cancer

J Jagieła, P Bartnicki, J Rysz - International Journal of Molecular Sciences, 2021 - mdpi.com
Acute kidney injury is a common complication of many medical procedures, including those
used in cancer treatment. Both chemotherapy and immunotherapy may result in …

[HTML][HTML] Emerging role of MiR-192-5p in human diseases

F Ren, Y Yao, X Cai, G Fang - Frontiers in Pharmacology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are a type of small non-coding RNAs that play an essential role in
numerous biological processes by regulating the post-transcriptional expression of target …