Immune Response to Mycobacterium tuberculosis: A Narrative Review

M De Martino, L Lodi, L Galli, E Chiappini - Frontiers in pediatrics, 2019 - frontiersin.org
The encounter between Mycobacterium tuberculosis (Mtb) and the host leads to a complex
and multifaceted immune response possibly resulting in latent infection, tubercular disease …

Immunology of Mycobacterium tuberculosis Infections

JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

[HTML][HTML] A functional role for antibodies in tuberculosis

LL Lu, AW Chung, TR Rosebrock, M Ghebremichael… - Cell, 2016 - cell.com
While a third of the world carries the burden of tuberculosis, disease control has been
hindered by a lack of tools, including a rapid, point-of-care diagnostic and a protective …

Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection

JD Simmons, CM Stein, C Seshadri, M Campo… - Nature Reviews …, 2018 - nature.com
Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

B cells and antibodies in the defense against Mycobacterium tuberculosis infection

JM Achkar, J Chan, A Casadevall - Immunological reviews, 2015 - Wiley Online Library
Better understanding of the immunological components and their interactions necessary to
prevent or control Mycobacterium tuberculosis (Mtb) infection in humans is critical for …

The role of B cells and humoral immunity in Mycobacterium tuberculosis infection

J Chan, S Mehta, S Bharrhan, Y Chen, JM Achkar… - Seminars in …, 2014 - Elsevier
Mycobacterium tuberculosis remains a major public health burden. It is generally thought
that while B cell-and antibody-mediated immunity plays an important role in host defense …

Clinical manifestations and immune response to tuberculosis

ML Carabalí-Isajar, OH Rodríguez-Bejarano… - World Journal of …, 2023 - Springer
Tuberculosis is a far-reaching, high-impact disease. It is among the top ten causes of death
worldwide caused by a single infectious agent; 1.6 million tuberculosis-related deaths were …

Immunology studies in non‐human primate models of tuberculosis

JAL Flynn, HP Gideon, JT Mattila… - Immunological reviews, 2015 - Wiley Online Library
Non‐human primates, primarily macaques, have been used to study tuberculosis for
decades. However, in the last 15 years, this model has been refined substantially to allow …

[HTML][HTML] Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas

Y Wang, Q Sun, Y Zhang, X Li, Q Liang, R Guo… - Journal of Infection, 2023 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, is currently the
deadliest infectious disease in human that can evolve to severe forms. A comprehensive …

[HTML][HTML] Antibodies and tuberculosis

AJ Jacobs, J Mongkolsapaya, GR Screaton… - Tuberculosis, 2016 - Elsevier
Tuberculosis (TB) remains a major public health problem internationally, causing 9.6 million
new cases and 1.5 million deaths worldwide in 2014. The Bacillus Calmette-Guérin vaccine …