Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now
threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we …

The Plasmodium falciparum proteasome constitutes a promising antimalarial target, with
multiple chemotypes potently and selectively inhibiting parasite proliferation and synergizing …

Whole genome sequencing (WGS) plays an important role in the advanced characterization
of pathogen transmission and is widely used in studies of major bacterial and viral diseases …

Introduction Malaria remains a devastating infectious disease with hundreds of thousands of
casualties each year. Antimalarial drug resistance has been a threat to malaria control and …

Background Timely molecular surveillance of Plasmodium falciparum kelch 13 (k13) gene
mutations is essential for monitoring the emergence and stemming the spread of artemisinin …

Atovaquone-proguanil (AP) is used as treatment for uncomplicated malaria, and as a
chemoprophylactic agent against Plasmodium falciparum. Imported malaria remains one of …

Current malaria treatments are threatened by drug resistance, and new drugs are urgently
needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S) …

Background: India represents 3% related to the global malaria problem. Early diagnosis and
treatment that are complete alongside preventive measures are modalities essential to …

The work included in this Ph. D. thesis was designed, generated, performed, and written by
Daniel Castañeda Mogollón at the University of Calgary in Calgary, Alberta, Canada. This …

In the last two decades' tremendous progress has been made towards global goals of
malaria control and elimination, yet there were still an estimated 227 million cases in 20191 …