More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Metastasis remains the leading cause of cancer-associated mortality, and a detailed
understanding of the metastatic process could suggest new therapeutic avenues. However …

Abstract N6-methyladenosine (m6A) methylation is an abundant modification in eukaryotic
mRNAs. Accumulating evidence suggests a role for RNA m6A methylation in various …

Osteosarcoma (OS) is the most common type of bone tumor that seriously affects limb
function and induces great pain in patients. Lung metastasis and chemotherapy resistance …

Despite advances in clinical diagnosis and treatment, the prognosis of patients with
osteosarcoma (OS) remains poor, and the treatment efficacy has plateaued. Therefore, it is …

Malignant osteosarcoma is one of the serious health concerns attributed to inferior
prognosis and uncontrolled metastasis in clinics. Indeed, multifunctional therapeutics with …

Preventing local tumor recurrence and simultaneously improving bone-tissue regeneration
are in great demand for osteosarcoma therapy. However, the current therapeutic implants …

BACKGROUND: Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts
differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation …

The postoperative tumor recurrence and chemotherapy resistance in clinical osteosarcoma
treatment have raised an imperative need to develop local implants for selectively killing …

Osteosarcoma (OS) is the most prevalent primary malignancy of bone. Inhibition of OS
recurrence and subsequent bone formation after surgery remains a challenge for decades …