▪ Abstract Extraordinary advances in molecular biology and biotechnology have led to the
development of a vast number of therapeutic anti-cancer agents. To reach cancer cells in a …

Nanoparticles for the detection and treatment of cancer have suffered from limited clinical
translation. A key problem has been the lack of understanding of the mechanisms of …

Cells respond to both chemical and mechanical cues present within their microenvironment.
Various mechanical signals are detected by and transmitted to the cells through …

Cancer cells exist in a constantly evolving tissue microenvironment of diverse cell types
within a proteinaceous extracellular matrix. As tumors evolve, the physical forces within this …

The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D)
microenvironment and involves a dynamic interplay between biochemical and mechanical …

In tissues, cells reside in confining microenvironments, which may mechanically restrict the
ability of a cell to double in size as it prepares to divide. How confinement affects cell cycle …

In this paper the theory of mixtures is used to develop a two‐phase model of an avascular
tumour, which comprises a solid, cellular, phase and a liquid phase. Mass and momentum …

In cancer, solid stresses impede the delivery of therapeutics to tumours and the trafficking
and tumour infiltration of immune cells. Understanding such consequences and the origin of …

Mathematical modeling, analysis and simulation are set to play crucial roles in explaining
tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial …

Despite a clinically recognized association between the lymphatics and metastasis, the
biology of tumor-lymphatic interaction is not clearly understood. We report here that …