Therapeutic use of metformin in prediabetes and diabetes prevention

U Hostalek, M Gwilt, S Hildemann - Drugs, 2015 - Springer
People with elevated, non-diabetic, levels of blood glucose are at risk of progressing to
clinical type 2 diabetes and are commonly termed 'prediabetic'. The term prediabetes …

Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose

RA DeFronzo, M Abdul-Ghani - The American journal of cardiology, 2011 - Elsevier
Individuals with impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG) are
at high risk, not only to develop diabetes mellitus, but also to experience an adverse …

Behavior matters

EB Fisher, ML Fitzgibbon, RE Glasgow… - American journal of …, 2011 - Elsevier
Behavior has a broad and central role in health. Behavioral interventions can be effectively
used to prevent disease, improve management of existing disease, increase quality of life …

[HTML][HTML] Genomics and genetics in the biology of adaptation to exercise

C Bouchard, T Rankinen… - Comprehensive Physiology, 2011 - ncbi.nlm.nih.gov
This chapter is devoted to the role of genetic variation and gene-exercise interactions in the
biology of adaptation to exercise. There is evidence from genetic epidemiology research that …

Metformin for diabetes prevention: update of the evidence base

U Hostalek, I Campbell - Current medical research and opinion, 2021 - Taylor & Francis
We have conducted a narrative review based on a structured search strategy, focusing on
the effects of metformin on the progression of non-diabetic hyperglycemia to clinical type 2 …

The association of hemoglobin a1c with incident heart failure among people without diabetes: the atherosclerosis risk in communities study

K Matsushita, S Blecker, A Pazin-Filho, A Bertoni… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE This study sought to investigate an association of HbA1c (A1C) with incident
heart failure among individuals without diabetes and compare it to fasting glucose …

Effect of long-term metformin and lifestyle in the diabetes prevention program and its outcome study on coronary artery calcium

RB Goldberg, VR Aroda, DA Bluemke… - Circulation, 2017 - Am Heart Assoc
Background: Despite the reduced incidence of coronary heart disease with intensive risk
factor management, people with diabetes mellitus and prediabetes remain at increased …

Regression from prediabetes to normal glucose regulation is associated with reduction in cardiovascular risk: results from the Diabetes Prevention Program outcomes …

L Perreault, M Temprosa, KJ Mather, E Horton… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE Restoration of normal glucose regulation (NGR) in people with prediabetes
significantly decreases the risk of future diabetes. We sought to examine whether regression …

Does diabetes prevention translate into reduced long-term vascular complications of diabetes?

DM Nathan, PH Bennett, JP Crandall, SL Edelstein… - Diabetologia, 2019 - Springer
The global epidemic of type 2 diabetes has prompted numerous studies and public health
efforts to reduce its development. A variety of interventions, including lifestyle modifications …

Reversion From Pre–Diabetes Mellitus to Normoglycemia and Risk of Cardiovascular Disease and All‐Cause Mortality in a Chinese Population: A Prospective Cohort …

X Liu, S Wu, Q Song, X Wang - Journal of the American Heart …, 2021 - Am Heart Assoc
Background It is unclear whether reversion from pre–diabetes mellitus to normoglycemia
reduces cardiovascular disease (CVD) and all‐cause mortality risk in a Chinese population …